The Iranian Journal of Obstetrics, Gynecology and Infertility

The Iranian Journal of Obstetrics, Gynecology and Infertility

Prevalence of Herpes Simplex Virus Type 1 and 2 (HSV-1 and HSV-2) in the Women with Breast Cancer by Multiplex-PCR method

Document Type : Original Article

Authors
Fatemeh Kaveh 1
Kumarss Amini 2
Mojtaba Sadeh 3
1 M.Sc. in Microbiology, School of Basic Sciences, Saveh Branch, Islamic Azad University, Saveh, Iran.
2 Assistant Professor, Department of Microbiology, School of Basic Sciences, Saveh Branch, Islamic Azad University, Saveh, Iran.
3 Medical Bacteriology Specialist, Department of Microbiology, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
10.22038/ijogi.2018.11070
Abstract
Introduction: Breast cancer is a common malignancy and a major cause of death in women. Viruses are considered as one of the risk factors associated with breast cancer. Herpes simplex virus-1 (HSV-1) and HSV-2 are involved in the pathogenesis of cancer. The present study was conducted to determine the frequency of HSV-1 and HSV-2 in the blood samples of patients with breast cancer using multiplex-polymerase chain reaction (M-PCR) technique.
methods: This cross-sectional study was conducted on 60 breast cancer patients within 2014-2015. The infection with HSV-1 and HSV-2 was investigated by M-PCR. All data were analyzed using SPSS software (version 18).
Results: Out of the 60 blood samples obtained from patients with breast cancer, 6 (10%) and 3 (5%) samples were positive for HSV-1 and HSV-2, respectively.
Conclusion: herpes simplex virus, especially HSV-1, can play a role as a cofactor in the incidence of breast cancer, so further studies are recommended in this area.
Keywords
Breast Cancer
Herpes Simplex Virus
Multiplex-PCR
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The Iranian Journal of Obstetrics, Gynecology and Infertility
Volume 21, Issue 3
May 2018
Pages 39-44