Comparison of therapeutic effects of insulin and glibenclamide in gestational diabetes
Maryam
Zangeneh
Assistant professor, Department of Obstetrics and Gynecology, High Risk Pregnancy Research Center, school of Medicine, Kermanshah University of Medical Science, Kermanshah, Iran.
author
Firoozeh
Veisi
Assistant professor, Department of Obstetrics and Gynecology, High Risk Pregnancy Research Center, school of Medicine, Kermanshah University of Medical Science, Kermanshah, Iran.
author
Behzad
Ebrahimi
Board of Anesthesiology, Department of Anesthesiology, school of Medicine, Kermanshah University of Medical Science, Kermanshah, Iran.
author
Negin
Rezavand
Assistant professor, Department of Obstetrics and Gynecology, High Risk Pregnancy Research Center, school of Medicine, Kermanshah University of Medical Science, Kermanshah, Iran.
author
text
article
2014
per
Introduction: Women with gestational diabetes due to concerns about teratogenicity and neonatal hypoglycemia are rarely treated with sulfonylureas. There is little information about the effects of these drugs in this group of women. This study was performed with the aim to compare the therapeutic effects of glibenclamide and insulin in treatment of gestational diabetes. Methods: This clinical randomized interventional study was performed on 90 women with gestational diabetes requiring treatment in 2010-2011. Women were randomly assigned to treatment with glibenclamide or insulin. Subcutaneous insulin 20 units twice a day was prescribed and, if needed, increased weekly. In the other group, 2.5 mg glibenclamide orally, once a day was started and if needed increased weekly up to a maximum dose of 20 mg. Treatment goal was fasting blood sugar 60-90 and after the food less than 120 mg/dl. Data were analyzed by SPSS software version 16 and Chi-square, independent t, Fisher exact and Mann-Whitney tests. PResults: Only one of the women in the glibenclamide group required to insulin for controlling blood sugar. There was no significantly difference between two groups in the percentage of infants with macrosomia (0.649), Oligohydramnios (0.304), policitemia (0.304), hypoglycemia (0.325), Polyhydramnios (0.778) and other neonatal complications. Conclusion: Glibenclamide has equivalent effectiveness with insulin in the treatment of gestational diabetes.
The Iranian Journal of Obstetrics, Gynecology and Infertility
Mashhad University of Medical Sciences
1680-2993
17
v.
124
no.
2014
1
7
https://ijogi.mums.ac.ir/article_3618_125d093c125e87eb3da061a9ab2d3b50.pdf
dx.doi.org/10.22038/ijogi.2014.3618
Evaluation of the frequency of unwanted pregnancy and its related factors in the pregnant women of Sarakhs city
Lida
Jarahi
Assistant Professor, Department of Social Medicine, Addiction Research Center, School of Medicine, Mashhad University of medical Sciences, Mashhad, Iran.
author
Abbas
Zavar
PhD student of Toxicology & Alcohol abuse, Addiction Research Centre, School of Medicine, Mashhad University of medical Sciences, Mashhad, Iran.
author
Mahboubeh
Neamat Shahi
Resident of Social Medicine, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
author
text
article
2014
per
Introduction: Unwanted pregnancy is a threat for maternal and neonatal health and is used as an indicator of community and reproductive health. Correct and effective use of contraception methods and proper training of women can cause protection against sexually transmitted diseases, proper childbearing interval, improving maternal and neonatal health and avoid from unwanted pregnancies. This study was performed with the aim to evaluate of the frequency of unwanted pregnancy and its related factors in the pregnant women of Sarakhs city. Methods: This descriptive-analytical study was performed on 300 pregnant mothers referring to rural and urban health care centers in Sarakhs city in 2011. Sampling method was convenient style. Data collection tools were a checklist of personal information’s and a questionnaire of 28 questions related to the beliefs of women and their husbands. Data were analyzed using the SPSS software (version 11.5), Chi-square test and logistic regression. PResults: 65 cases (21.7%) of women reported unwanted pregnancies. There were significant association between wanted and unwanted pregnancies with women's age (P=0.001), history of of unwanted pregnancy (P=0.04), ethnicity (P=0.02), education (P=0.03), family income (P=0.002), job (p=0.001), information of husband about contraception methods (P=0.006), participation of husband in prevention of pregnancy (P= 0.04), and partner participation in contraception (p=0.04), child number (P=0.04), number of child (P=0.04), and number of previous pregnancies (P=0.01). Attempted abortions were reported in 16.9% of unwanted pregnancies. Conclusions: High rates of unwanted pregnancies is associated with incorrect use of contraceptive methods, lack of men's participation in the program of family planning, previous history of unwanted pregnancy. Training of women and participation of men are important for prevention of risky and unwanted pregnancies.
The Iranian Journal of Obstetrics, Gynecology and Infertility
Mashhad University of Medical Sciences
1680-2993
17
v.
124
no.
2014
8
14
https://ijogi.mums.ac.ir/article_3615_8043378bfd0af7fcbbdf236920e64e0e.pdf
dx.doi.org/10.22038/ijogi.2014.3615
Cervical cancer in pregnancy: Diagnostic and therapeutic challenges
Monireh
Toosi
M.Sc. of Midwifery, School of Nursing and Midwifery, Shiraz University of Medical Sciences, Shiraz, Iran.
author
Mohammad
Mohammadian Panah
Associate Professor, Department of Radiation Oncology, Colorectal Research Center, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran
author
Sareh
Hoseini
Assistant Professor, Department of Radiation Oncology, Solid Tumor Research Center, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
author
Zohreh
Yousefi
Professor, Department of Obstetrics and Gynecology, Ovulation Disorder Research Center, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
author
text
article
2014
per
Introduction: Cancer is the second most common cause of death in women during reproductive ages; however, the occurrence of cancer during pregnancy is very uncommon. With increasing the rate of pregnancies in advanced ages, the incidence of cancer during pregnancy is also being increased. Cervical cancer is one of the most common cancers presenting during pregnancy. This study was performed aimed to review the most important diagnostic and therapeutic approaches in patients with cervical cancer during pregnancy. Methods: in this narrative review article, the most recent research, reviews, guideline articles and current evidences were selected and reviewed with the main keywords of pregnancy, cancer, cervical, diagnosis, chemotherapy, radiation and surgery and its equivalents; then, the most important and strongest diagnostic and therapeutic recommendations were provided. 34 articles used in this study consisted of all articles in the PubMed database in the time period of 2000 to 2014. Results: Approximately 1-3% of all cervical cancers are diagnosed during pregnancy, breast-feeding or one year following delivery. Pregnancy is a good opportunity for early diagnosis of cervical cancer. Maternal and fetal health is the most important diagnostic and therapeutic challenges in pregnancy. Fortunately, due to routine health care service and screening during pregnancy, most cervical cancers are detected in early stage. However, due to concern about fetus safety, there are many limitations and contraindications for using diagnostic and therapeutic methods during pregnancy. Treatment type depends on disease stage, tumor histology and gestational age and should be individually determined in each case. Conclusion: Cervical cancer in pregnancy can be treated successfully. In general, by considering a balance between the mother health and fetal health as the primary goal, evidence-based therapeutic approaches can be used in these patients. Survival of the mother should not be compromised due to delay in beginning of treatment.
The Iranian Journal of Obstetrics, Gynecology and Infertility
Mashhad University of Medical Sciences
1680-2993
17
v.
124
no.
2014
15
21
https://ijogi.mums.ac.ir/article_3617_3f65567aaee068b4825c96cb41011cfd.pdf
dx.doi.org/10.22038/ijogi.2014.3617