Comparison of Serum Levels of HSP70 and CA125 in Patients with Epithelial Ovarian Cancer and Patients with Benign Ovarian Masses
Zohreh
Yousefi
Professor, Department of Obstetrics and Gynecology, Ovulation Dysfunction Research Center, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
author
Maliheh
Hasanzadeh Mofrad
Associate Professor, Department of Obstetrics and Gynecology, Ovulation Dysfunction Research Center, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
author
Zahra
Kazemianfar
Resident of Obstetrics and Gynecology, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
author
Hosein
Ayatollahi
Associate Professor, Department of Cytopathology, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
author
Fatemeh
Tavassoli
Associate Professor, Department of Obstetrics and Gynecology, Ovulation Dysfunction Research Center, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
author
Mahtab
Beyranvandi
Resident of Obstetrics and Gynecology, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
author
Monavar
Afzal Aghayi
Assistant Professor, Department of Biostatistics, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
author
text
article
2014
per
Introduction: Ovarian cancer is one of the most common gynecological malignancies with high mortality rate. This high mortality rate may be due to delay in diagnosis. Using tumor-specific markers that are sensitive in the early stages of cancer is very effective to improve results of therapy. The aim of this study was evaluation of the diagnostic value of serum levels of Heat-shock protein 70 and CA125 in patients with epithelial ovarian tumors. Methods: This analytical study was conducted on 37 patients with epithelial ovarian cancer and 35 patients with benign ovarian masses in 2011-2012. Blood samples were taken from all patients before the surgery. Patients with ovarian cancer underwent cytoreductive surgery and tumor staging. Also, patients with benign ovarian masses underwent cystectomy or oophorectomy. Serum levels of HSP70 and CA125 were measured by ELISA and RIA, respectively. Finally, HSP70 and CA125 levels were compared before surgery between two groups. Data were analyzed by SPSS software version 16 and Fisher, chi-square, t-student, Mann-Whitney, and ANOVA tests. P value less than 0.05 was considered significant. Results: Mean age of patients with malignant ovarian cancer was significantly higher than the benign ovarian masses group (p<0.001). Pain was the most prevalent symptom in 62.5% of cases in both groups. Mean levels of CA125 and HSP70 were respectively 672.95±470.55 and 0.859±0.461 in patients with ovarian cancer. The mean levels of CA125 and HSP70 in epithelial ovarian cancer was significantly higher than benign ovarian masses group (p=0.025 and p=0.001, respectively). Conclusion: HSP70 along with CA125 can be useful for early detection of malignant ovarian cancers.
The Iranian Journal of Obstetrics, Gynecology and Infertility
Mashhad University of Medical Sciences
1680-2993
17
v.
101
no.
2014
1
5
https://ijogi.mums.ac.ir/article_2913_f2eade4492da454b59b63b8cac7f142f.pdf
dx.doi.org/10.22038/ijogi.2014.2913
Effects of Intravaginal Application of Seminal Plasma on Embryo Implantation and Early Abortion Rate in Patients Undergoing Intracytoplasmic Sperm Injection
Sariyeh
Golmahammad Lou
Associate Professor of Obstetrics and Gynecology, Reproductive Health Research Center, Urmia University of Medical Sciences, Urmia, Iran.
author
Masomeh
Hagshafiha
Associate Professor of Obstetrics and Gynecology, Reproductive Health Research Center, Urmia University of Medical Sciences, Urmia, Iran.
author
Zahra
yekta
Associate Professor of Community Medicine , Reproductive Health Research Center, Urmia University of Medical Sciences, Urmia, Iran.
author
Sima
Oshnouei
M.Sc. of Epidemiology, Reproductive Health Research Center, Urmia University of Medical Sciences, Urmia, Iran.
author
Elham
Firoozi
Resident of Obstetrics and Gynecology, School of Medicine, Urmia University of Medical Sciences, Urmia, Iran.
author
Sarvin
Pashapoor
Medical Student, School of Medicine, Urmia University of Medical Sciences, Urmia, Iran.
author
Yaghob
Deldar
M.Sc. of Clinical Chemistry, School of Medicine, Urmia University of Medical Sciences, Urmia, Iran.
author
Vida
Saidi
B.Sc of Nursing, School of Medicine, Urmia University of Medical Sciences, Urmia, Iran.
author
text
article
2014
per
Introduction: Semen is one of the factors in preparing endometrium for embryo implantation. This is in contrast with public believed that immune response to antigen in ejaculated semen will disrupt fertility and pregnancy. The aim of this study was investigation of the influence of seminal plasma injection on Intracytoplasmic Sperm Injection (ICSI) success among infertile couples. Methods: This clinical trial was conducted on 140 infertile couples undergoing ICSI treatment in Kosar infertility clinic and reproductive health research center of Urmia, Iran during 2010-2011. Couples were randomly divided into seminal plasma injection and control groups. Cry preserved seminal plasma was prepared 30-60 minutes before embryo transferring. bHCG test and sonography was performed respectively at day 14 and between 6th to 12th weeks after embryo transfer. Outcomes were compared between two groups. Data were analyzed by SPSS software version 16 and chi-square test. P value less than 0.05 was considered significant. Results: There were no significant differences in number of oocyte, quantity and quality of transferred embryo between two groups (p>0.05). Rate of implantation based on βHCG results were 24.3% (17 women) in intervention group and 25.5% (18 women) in control group. Rate of abortion was 18.7% (n=2) and 11.1% (n=3) in intervention and control groups, respectively. There were no significant differences in implantation rate (p=1) and early abortion rate (p=0.5) between two groups. Conclusion: Intravaginal application of seminal plasma has no effects on fertility outcomes in patients undergoing ICSI treatment.
The Iranian Journal of Obstetrics, Gynecology and Infertility
Mashhad University of Medical Sciences
1680-2993
17
v.
101
no.
2014
6
12
https://ijogi.mums.ac.ir/article_2915_8e63cf5798c4dddcefc2355de6f16ee7.pdf
dx.doi.org/10.22038/ijogi.2014.2915
Assessment of Dairy Products, Dietary Calcium and Vitamin D Intake in Patients with Breast Cancer
Akram
Kooshki
Ph.D. of Nutrition Sciences, Traditional and Complementary, School of Medicine, Sabzevar University of Medical Sciences, Sabzevar, Iran.
author
Roya
Akbarzadeh
Lecturer of Anesthesiology, School of Paramedical, Sabzevar University of Medical Sciences, Sabzevar, Iran.
author
text
article
2014
per
Introduction: Semen is one of the factors in preparing endometrium for embryo implantation. This is in contrast with public believed that immune response to antigen in ejaculated semen will disrupt fertility and pregnancy. The aim of this study was investigation of the influence of seminal plasma injection on Intracytoplasmic Sperm Injection (ICSI) success among infertile couples. Methods: This clinical trial was conducted on 140 infertile couples undergoing ICSI treatment in Kosar infertility clinic and reproductive health research center of Urmia, Iran during 2010-2011. Couples were randomly divided into seminal plasma injection and control groups. Cry preserved seminal plasma was prepared 30-60 minutes before embryo transferring. bHCG test and sonography was performed respectively at day 14 and between 6th to 12th weeks after embryo transfer. Outcomes were compared between two groups. Data were analyzed by SPSS software version 16 and chi-square test. P value less than 0.05 was considered significant. Results: There were no significant differences in number of oocyte, quantity and quality of transferred embryo between two groups (p>0.05). Rate of implantation based onβHCG results were 24.3% (17 women) in intervention group and 25.5% (18 women) in control group. Rate of abortion was 18.7% (n=2) and 11.1% (n=3) in intervention and control groups, respectively. There were no significant differences in implantation rate (p=1) and early abortion rate (p=0.5) between two groups. Conclusion: Intravaginal application of seminal plasma has no effects on fertility outcomes in patients undergoing ICSI treatment.
The Iranian Journal of Obstetrics, Gynecology and Infertility
Mashhad University of Medical Sciences
1680-2993
17
v.
101
no.
2014
13
18
https://ijogi.mums.ac.ir/article_2916_718952195d67e13a94909900771fce90.pdf
dx.doi.org/10.22038/ijogi.2014.2916