تأثیر شش هفته تمرین هوازی بر ترکیب بدنی و سطح سرمی IL-10 در زنان میانسال چاق

نوع مقاله: اصیل پژوهشی

نویسندگان

1 استادیار گروه فیزیولوژری ورزشی، دانشکده تربیت بدنی و علوم ورزشی،‌ دانشگاه آزاد اسلامی، واحد اسلامشهر، تهران، ایران.

2 استادیار گروه فیزیولوژری ورزشی، دانشکده علوم انسانی،‌ دانشگاه آزاد اسلامی، واحد ساوه، ساوه، ایران.

چکیده

مقدمه: اینترلوکین 10 (IL-10)، یک سایتوکین ضد التهابی است که سطوح آن در حضور چاقی و بیماری‌های وابسته کاهش می‌‌یابد. با توجه به عدم مطالعات کافی در این زمینه بر روی زنان چاق سالم یا بیمار، مطالعه حاضر با هدف تعیین اثر تمرینات کوتاه مدت هوازی بر سطوح سرمی IL-10 در زنان چاق انجام گرفت.
روش‌کار: این مطالعه در تابستان سال 1395 بر روی 30 نفر از زنان چاق میانسال کم‌تحرک (با شاخص توده بدنی بیشتر یا مساوی 30 و کمتر یا مساوی 36 کیلوگرم بر متر مربع) در دامنه سنی 40-30 سال در تهران انجام شد. افراد به دو گروه 15 نفره تجربی و کنترل تقسیم شدند. گروه تجربی یک برنامه تمرینات هوازی را 3 جلسه در هفته به مدت 6 هفته با زمان 45-30 دقیقه با شدت 75-60% ضربان قلب بیشینه اجرا نمودند. چاقی شکمی و دیگر شاخص‌های آنتروپومتریکی و همچنین سطح سرمی IL-10، 48 ساعت قبل و پس از مداخله ورزشی اندازه‌گیری شد. تجزیه و تحلیل داده‌ها با استفادهاز نرم‌افزار آماری SPSS (نسخه 15) و آزمون‌های تی مستقل و تی وابسته انجام شد. میزان p کمتر از 05/0 معنی‌دار در نظر گرفته شد.
یافته‌ها: در گروه تجربی کاهش معنی‌داری در وزن بدن، شاخص توده بدنی، درصد چربی بدن و چاقی شکمی مشاهده شد (05/0>p). همچنین سطح سرمی IL-10 در گروه تجربی افزایش معنی‌داری یافت (001/0=p).
نتیجه‌گیری: تمرینات هوازی کوتاه مدت با شدت متوسط تا شدید به کاهش شاخص‌های معرف چاقی و افزایش سطوح سرمی IL-6 در زنان چاق منجر می‌شود.

کلیدواژه‌ها


عنوان مقاله [English]

The effect of six weeks aerobic training on body composition and serum level of IL-10 in middle-aged obese females

نویسندگان [English]

  • Laleh Behboudi 1
  • Mojtaba Izadi 2
1 Assistant professor, Department of Exercise Physiology, School of Physical Education and Exercise Sciences, Islamshahr Branch, Islamic Azad University, Tehran, Iran
2 Assistant professor, Department of Exercise Physiology, School of Human Sciences, Saveh Branch, Islamic Azad University, Saveh, Iran.
چکیده [English]

Introduction: Interleukin 10 (IL-10) is an anti-inflammatory cytokine that its levels decrease in the presence of obesity and related diseases. Due to the lack of sufficient studies in this regard on healthy or patient obese women; this study was performed with aim to determine the effect of short term aerobic training on serum IL-10 in obese women.
Methods: This study was performed in summer 2016 on 30 sedentary middle-aged obese females aged 30-40 years (30≤BMI≤36 kg/m2) in Tehran, Iran. Subjects were divided into experimental (n=15) and control (n=15) groups. Experimental group underwent an aerobic training program for 6 weeks, 3 sessions per week with 30-45 minutes at 60 to 75% of the heart rate max. Abdominal obesity and other anthropometrical markers. as well serum IL-10 were measured at 48 hours before and after exercise intervention. Data were analyzed by SPSS software (version 15) and independent-t and dependent-t tests. P<0.05 was considered significant.
Results: Significant increase were observed in body weight, BMI, body fat percentage and abdominal obesity in experimental group (p<0.05). Also, serum IL-10 level significantly increased in exercise group (p = 0.001).
Conclusion: Short term aerobic training with moderate to high intensity leads to decreased obesity determinative indexes and increased serum IL-10 in obese females.

کلیدواژه‌ها [English]

  • Aerobic training
  • Anti-inflammation
  • Cardiovascular fitness
  • Obesity
  1. Paredes-Turrubiarte G, González-Chávez A, Pérez-Tamayo R, Salazar-Vázquez BY, Hernández VS, Garibay-Nieto N, et al. Severity of non-alcoholic fatty liver disease is associated with high systemic levels of tumor necrosis factor alpha and low serum interleukin 10 in morbidly obese patients. Clin Exp Med 2016; 16(2):193-202.
  2. Santilli F, Blardi P, Scapellato C, Bocchia M, Guazzi G, Terzuoli L, et al. Decreased plasma endogenous soluble RAGE, and enhanced adipokine secretion, oxidative stress and platelet/coagulative activation identify non-alcoholic fatty liver disease among patients with familial combined hyperlipidemia and/or metabolic syndrome. Vascul Pharmacol 2015; 72:16-24.
  3. Vinagre I, Sánchez-Quesada JL, Sánchez-Hernández J, Santos D, Ordoñez-Llanos J, De Leiva A, et al. Inflammatory biomarkers in type 2 diabetic patients: effect of glycemic control and impact of LDL subfraction phenotype. Cardiovasc Diabetol 2014; 13:34.
  4. Chan IH, Van Hoof D, Abramova M, Bilardello M, Mar E, Jorgensen B, et al. PEGylated IL-10 Activates Kupffer Cells to Control Hypercholesterolemia. PLoS One 2016; 11(6):e0156229.
  5. Nishida M, Moriyama T, Sugita Y, Yamauchi-Takihara K. Interleukin-10 associates with adiponectin predominantly in subjects with metabolic syndrome. Circ J 2007; 71(8):1234-8.
  6. van Exel E, Gussekloo J, de Craen AJ, Bootsma-van der Wiel A, Frölich M, Westendorp RG. Inflammation and stroke: the Leiden 85-plus study. Stroke 2002; 33(4):1135-8.
  7. van Exel E, Gussekloo J, de Craen AJM, Frölich M, Bootsma-van der Wiel A, Westendorp RG. Low production capacity of interleukin-10 associates with the metabolic syndrome and type2 diabetes. Diabetes 2002; 51(4):1088-92.
  8. Eizadi M, Karimy M, Kohandel M, Doaly H. Effect of aerobic exercise on serum leptin response and insulin resistance of patients with type 2 diabetes. J Qazvin Univ Med Sci 2013; 16(4):33-9.
  9. Hammett CJ, Prapavessis H, Baldi JC, Varo N, Schoenbeck U, Ameratunga R, et al. Effects of exercise training on 5 inflammatory markers associated with cardiovascular risk. Am Heart J 2006; 151(2):367.e7-16.
  10. Bautmans I, Njemini R, Vasseur S, Chabert H, Moens L, Demanet C, et al. Biochemical changes in response to intensive resistance exercise training in the elderly. Gerontology 2005; 51(4):253-65.
  11. Lambert CP, Wright NR, Finck BN, Villareal DT. Exercise but not diet induced weight loss decreases skeletal muscle inflammatory gene expression in frail obese elderly. J Appl Physiol (1985) 2008; 105(2):473-8.
  12. Ribeiro F, Alves AJ, Teixeira M, Miranda F, Azevedo C, Duarte JA, et al. Exercise training increases interleukin-10 after an acute myocardial infarction: a randomized clinical trial. Int J Sports Med 2012; 33(3):192-8.
  13. Kadoglou NP, Iliadis F, Angelopoulou N, Perrea D, Ampatzidis G, Liapis CD, et al. The anti-inflammatory effects of exercise training in patients with type 2 diabetes mellitus. Eur J Cardiovasc Prev Rehabil 2007; 14(6):837-43.
  14. Haghshenas R, Gilani N, Jafari M. Effect of 16 weeks endurance training and high fat diet on plasma level of interleukins-6, 10 and nesfatin-1 of rats. Sport Physiol 2015; 6(24):49-61 (Persian).
  15. Phillips MD, Patrizi RM, Cheek DJ, Wooten JS, Barbee JJ, Mitchell JB. Resistance training reduces subclinical inflammation in obese, postmenopausal women. Med Sci Sports Exerc 2012; 44(11):2099-110.
  16. Haghshenas R, Ravasi AA, Kordi MR, Hedayati M, Shabkhiz F, Shariatzadeh M. The effect of a 12-week endurance training on IL-6, IL-10 and Nesfatin -1 plasma level of obese male rats. J Sport Biosci 2013; 5(4):109-22 (Persian).
  17. Jenkins NT, Padilla J, Arce-Esquivel AA, Bayless DS, Martin JS, Leidy HJ, et al. Effects of endurance exercise training, metformin, and their combination on adipose tissue leptin and IL-10 secretion in OLETF rats. J Appl Physiol (1985) 2012; 113(12):1873-83.
  18. Batista ML Jr, Lopes RD, Seelaender MC, Lopes AC. Anti-inflammatory effect of physical training in heart failure: role of TNF-alpha and IL-10. Arq Bras Cardiol 2009; 93(6):643-51.
  19. Phillips MD, Patrizi RM, Cheek DJ, Wooten JS, Barbee JJ, Mitchell JB. Resistance training reduces subclinical inflammation in obese, postmenopausal women. Med Sci Sports Exerc 2012; 44(11):2099-110.
  20. Leggate M, Carter WG, Evans MJ, Vennard RA, Sribala-Sundaram S, Nimmo MA. Determination of inflammatory and prominent proteomic changes in plasma and adipose tissue after high-intensity intermittent training in overweight and obese males. J Appl Physiol (1985) 2012; 112(8):1353-60.
  21. Brunelli DT, Chacon-Mikahil MP, Gáspari AF, Lopes WA, Bonganha V, Bonfante IL, et al. Combined training reduces subclinical inflammation in obese middle-age men. Med Sci Sports Exerc 2015; 47(10):2207-15.
  22. Zwetsloot KA, John CS, Lawrence MM, Battista RA, Shanely RA. High-intensity interval training induces a modest systemic inflammatory response in active, young men. J Inflamm Res 2014; 7:9-17.
  23. Pedersen BK. The anti-inflammatory effect of exercise: its role in diabetes and cardiovascular disease control. Essays Biochem 2006; 42:105-17.
  24. Pereira GB, Tibana RA, Navalta J, Sousa NM, Córdova C, Souza VC, et al. Acute effects of resistance training on cytokines and osteoprotegerin in women with metabolic syndrome. Clin Physiol Funct Imaging 2013; 33(2):122-30.
  25. Tedgui A, Mallat Z. Anti-inflammatory mechanisms in the vascular wall. Circ Res 2001; 88(9):877-87.
  26. Calcaterra V, De Amici M, Klersy C, Torre C, Brizzi V, Scaglia F, et al. Adiponectin, IL-10 and metabolic syndrome in obese children and adolescents. Acta Biomed 2009; 80(2):117-23.
  27. Esposito K, Pontillo A, Giugliano F, Giugliano G, Marfella R, Nicoletti G, et al. Association of low interleukin-10 levels with the metabolic syndrome in obese women. J Clin Endocrinol Metab 2003; 88(3):1055-8.
  28. Smith DA, Irving SD, Sheldon J, Cole D, Kaski JC. Serum levels of the anti-inflammatory cytokine interleukin-10 are decreased in patients with unstable angina. Circulation 2001; 104(7):746-9.
  29. van Exel E, Gussekloo J, de Craen AJM, Bootsma-van der Wiel A, Frolich M, Westendorp RG. Inflammation and stroke: the Leiden 85-plus study. Stroke 2002; 33(4):1135-8.
  30. Westendorp RG, Langermans JA, Huizinga TW, Elouali AH, Verweij CL, Boomsma DI, et al. Genetic influence on cytokine production and fatal meningococcal disease. Lancet 1997; 349(9046):170-3.
  31. Johnson WD, Brashear MM, Gupta AK, Rood JC, Ryan DH. Incremental weight loss improves cardiometabolic risk in extremely obese adults. Am J Med 2011; 124(10):931-8.
  32. Babbitt DM, Diaz KM, Feairheller DL, Sturgeon KM, Perkins AM, Veerabhadrappa P, et al. Endothelial activation microparticles and inflammation status improve with exercise training in African Americans. Int J Hypertens 2013; 2013:538017.
  33. Shabani R, Yosefizad L, Fallah F. Effects of eight weeks of endurance-resistance training on some inflammatory markers and cardiovascular endurance in sedentary postmenopausal women. Iran J Obstet Gynecol Infertil 2017; 20(1):23-30. (Persian).
  34. Stavropoulos-Kalinoglou A, Metsios GS, Veldhuijzen van Zanten JJ, Nightingale P, Kitas GD, Koutedakis Y. Individualised aerobic and resistance exercise training improves cardiorespiratory fitness and reduces cardiovascular risk in patients with rheumatoid arthritis. Ann Rheum Dis 2013; 72(11):1819-25.
  35. Wärnberg J, Cunningham K, Romeo J, Marcos A. Physical activity, exercise and low-grade systemic inflammation. Proc Nutr Soci 2010; 69(3):400-6.
  36. McGavock JM, Mandic S, Vonder Muhll I, Lewanczuk RZ, Quinney HA, Taylor DA, et al. Low cardiorespiratory fitness is associated with elevated C-reactive protein levels in women with type 2 diabetes. Diabetes Care 2004; 27(2):320–5.
  37. Aronson D, Sheikh-Ahmad M, Avizohar O, Kerner A, Sella R, Bartha P, et al. C-reactive protein is inversely related to physical fitness in middle-aged subjects. Atherosclerosis 2004; 176(1):173-9.
  38. Nieman DC, Konrad M, Henson DA, Kennerly K, Shanely RA, Wallner-Liebmann SJ. Variance in the acute inflammatory response to prolonged cycling is linked to exercise intensity. J Interferon Cytokine Res 2012; 32(1):12-7.
Lopes WA, Leite N, da Silva LR, Brunelli DT, Gáspari AF, Radominski RB, et al. Effects of 12 weeks of combined training without caloric restriction on inflammatory markers in overweight girls. J Sports Sci 2016; 34(20):1902-12