نقش ویتامین D در سلامت باروری زنان و مردان: یک مطالعه مروری

نوع مقاله: مروری

نویسندگان

1 دانشجوی دکترای تخصصی بهداشت باروری، کمیته تحقیقات دانشجویی، دانشکده پرستاری و مامایی، دانشگاه علوم پزشکی مشهد، مشهد، ایران.

2 دانشیار گروه مامایی، مرکز تحقیقات مراقبت مبتنی بر شواهد، دانشکده پرستاری و مامایی، دانشگاه علوم پزشکی مشهد، مشهد، ایران.

3 کارشناس مامایی، دانشکده پزشکی، دانشگاه علوم پزشکی مشهد، مشهد، ایران.

چکیده

مقدمه: کمبود ویتامین Dدر سنین باروری امری شایع است. مطالعات اخیر نشان می­دهد که کمبود ویتامین Dبا کارکردهای ضعیف تولید‌مثل در زنان و مردان سنین باروری همراه است. لذا مطالعه حاضر با هدف تعیین نقش ویتامین D بر برخی عملکردهای تولید مثلی انسان (مانند سندرم تخمدان پلی‌کیستیک، آندومتریوز، میوم، نارسایی زودرس تخمدان‌ها، ناباروری مردان و IVF) انجام شد.
روش‌کار: در این مطالعه مروری، مطالعات انجام شده فارسی و انگلیسی در طی سال‌های 1378 تا آبان ماه 1395، با استفاده از کلید واژه‌های فارسی ویتامین D، باروری، ناباروری و کلید واژه‌های انگلیسی fertility، infertility، vitamin D، در پایگاه‌های اطلاعاتی معتبر SID، Iranmedx، Scopus، Irandoc، PubMed، Magiran و Google scholar جستجو شدند.
یافته‌ها: 35 مقاله استخراج شده از 302 مطالعه در ارتباط با نقش ویتامین D در عملکرد تولید مثلی انسان مورد بررسی قرار گرفت. نتایج حاصل از آخرین مطالعات انجام شده دراین زمینه مورد بحث قرار گرفت و خلاصه شد.
نتیجه­گیری: کمبود ویتامین Dکه به عنوان سطح سرمی کمتر از 20 نانوگرم در میلی‌لیتر در نظر گرفته می‌شود، در سنین باروری شایع است و کمبود ویتامین D در عملکردهای تولید مثل مانند سندرم تخمدان پلی‌کیستیک، فیبروم رحمی، پارامترهای نامناسب اسپرم و در شکست درمان IVF نقش دارد، بنابراین مکمل ویتامین Dدر درمان ناباروری زنان و مردان توصیه می‌شود.

کلیدواژه‌ها


عنوان مقاله [English]

The Role of Vitamin D in Male and Female Reproductive Health: A Review Study

نویسندگان [English]

  • Morvarid Irani 1
  • Khadijeh Mirzaei 2
  • Nahid Maleki 1
  • Ensieh Entezari 3
1 1. Research Committee, School of Nursing and Midwifery, Mashhad University of Medical Sciences, Mashhad, Iran
2 Associate Professor, Department of Midwifery, Evidence-based Care Research Center, School of Nursing and Midwifery, Mashhad University of Medical Sciences, Mashhad, Iran
3 BC of Midwifery, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
چکیده [English]

Introduction: Vitamin D deficiency is common during reproductive age. Recent data suggest that vitamin D deficiency is associated with poor reproductive function in women and men. Therefore, this study was performed with aim to determine the role of vitamin D on some reproductive function (such as polycystic ovary syndrome, endometriosis, myoma, premature ovary failure, male infertility, and in vitro fertilization (IVF).
Methods: In this review study, Persian and English articles that published during 1997 to 2016 with keywords of vitamin D, infertility, fertility were searched in PubMed, Magiran, Google Scholar, Iranmedex, Scopus, Irandoc and SID databases.
Results: A total of 35 studies which were extracted from 302 articles related to the role of vitamin D on some reproductive function were studied. The results of latest research articles in this field were discussed and summarized.
Conclusion: Deficiency of vitamin D defined as serum concentration of <20 ng/ml is common in reproductive age. Vitamin D deficiency has a role in reproductive dysfunction, such as polycystic ovary syndrome, uterine fibroids, abnormal semen parameters and in IVF failure. So, vitamin D supplementation is advised in infertility therapy in both male and female.

کلیدواژه‌ها [English]

  • Assisted reproductive techniques
  • Endometriosis infertility
  • Infertility
  • in vitro fertilization
  • Male Infertility
  • Myoma infertility
  • Premature ovary failure
  • Polycystic ovary syndrome
  • Vitamin D
  1. Lerchbaum E, Rabe T. Vitamin D and female fertility. Curr Opin Obstet Gynecol 2014; 26(3):145–50.
  2. Grzechocinska B, Dabrowski FA, Cyganek A, Wielgos M. The role of vitamin D in impaired fertility treatment. Neuro Endocrinol Lett 2013; 34(8):756–62.
  3. Seremak-Mrozikiewicz A, Drews K, Mrozikiewicz PM, Bartkowiak-Wieczorek J, Marcinkowska M, Wawrzyniak A, et al. Correlation of vitamin D receptor gene (VDR) polymorphism with osteoporotic changes in Polish postmenopausal women. Neuro Endocrinol Lett 2009; 30(4):540–6.
  4. Holick MF. The vitamin D deficiency pandemic: a forgotten hormone important for health. Public Health Rev 2006; 32(1):267-83
  5. Deluca HF. Overview of general physiologic features and functions of Vitamin D. Am J Clin Nutr 2004; 80(6 Suppl):1689S-96.
  6. Armas LA, Hollis BW, Heaney RP. Vitamin D2 is much less effective than Vitamin D3 in human. J Clin Endocrinol Metab. 2004; 89(11):5387-91.
  7. McCullough M. Vitamin D deficiency in pregnancy: bringing the issues to light. J Nutr 2007; 137(2):305-6.
  8. Wagner CL, Greer FR. Prevention of rickets and vitamin D deficiency in infants, children and adolescents. Pediatrics 2008; 122(5):1142-52.
  9. Rosen CJ, Abrams SA, Aloia JF, Brannon PM, Clinton SK, Durazo-Arvizu RA, et al. IOM committee members respond to Endocrine Society vitamin D guideline. J Clin Endocrinol Metab 2012; 97(4):1146–52.
  10. Christakos S, Dhawan P, Benn B, Porta A, Hediger M, Oh GT, et al. Vitamin D: molecular mechanism of action. Ann N Y Acad Sci 2007; 1116:340–8.
  11. Weisman Y, Harell A, Edelstein S, David M, Spirer Z, Golander A. 1 alpha, 25-Dihydroxyvitamin D3 and 24,25-dihydroxyvitamin D3 in vitro synthesis by human decidua and placenta. Nature 1979; 281(5729):317–9.
  12. Evans KN, Nguyen L, Chan J, Innes BA, Bulmer JN, Kilby MD, et al. Effects of 25-hydroxyvitamin D3 and 1,25-dihydroxyvitamin D3 on cytokine production by human decidual cells. Biol Reprod 2006; 75(6):816–22.
  13. Parikh G, Varadinova M, Suwandhi P, Araki T, Rosenwaks Z, Poretsky L, et al. Vitamin D regulates steroidogenesis and insulin-like growth factor binding protein-1 (IGFBP-1) production in human ovarian cells. Horm Metab Res 2010; 42(10):754–7.
  14. Luk J, Torrealday S, Neal Perry G, Pal L. Relevance of vitamin D in reproduction. Hum Reprod 2012; 27(10):3015–27.
  15. Badawy A, Elnashar A. Treatment options for polycystic ovary syndrome. Int J Womens Health 2011; 3:25-35.
  16. Azziz R, Carmina E, Dewailly D, Diamanti-Kandarakis E, Escobar-Morreale HF, Futterweit W, et al. Positions statement: criteria for defining polycystic ovary syndrome as a predominantly hyperandrogenic syndrome: an androgen excess society guideline. J Clin Endocrinol Metab 2006; 91(11):4237–45.
  17. Azziz R. Diagnosis of polycystic ovarian syndrome: the rotterdam criteria are premature. J Clin Endocrinol Metab 2006; 91(3):781–5.
  18. Thomson RL, Spedding S, Buckley JD. Vitamin D in the aetiology and management of polycystic ovary syndrome. Clin Endocrinol (Oxf) 2012; 77(3):343–50.
  19. Patra SK, Nasrat H, Goswami B, Jain A. Vitamin D as a predictor of insulin resistance in polycystic ovarian syndrome. Diabetes Metab Syndr 2012; 6(3):146–9.
  20. Wehr E, Pilz S, Schweighofer N, Giuliani A, Kopera D, Pieber TR, et al. Association of hypovitaminosis D with metabolic disturbances in polycystic ovary syndrome. Eur J Endocrinol 2009; 161(4):575–82.
  21. Yildizhan R, Kurdoglu M, Adali E, Kolusari A, Yildizhan B, Sahin HG, et al. Serum 25-hydroxyvitamin D concentrations in obese and non-obese women with polycystic ovary syndrome. Arch Gynecol Obstet 2009; 280(4):559–63.
  22. Ott J, Wattar L, Kurz C, Seemann R, Huber JC, Mayerhofer K, et al. Parameters for calcium metabolism in women with polycystic ovary syndrome who undergo clomiphene citrate stimulation: a prospective cohort study. Eur J Endocrinol 2012; 166(5):897–902.
  23. Hahn S, Haselhorst U, Tan S, Quadbeck B, Schmidt M, Roesler S, et al. Low serum 25-hydroxyvitamin D concentrations are associated with insulin resistance and obesity in women with polycystic ovary syndrome. Exp Clin Endocrinol Diabetes 2006; 114(10):577-83.
  24. Christakos, Sylvia, et al. "New insights into the function and regulation of vitamin D target proteins." The Journal of steroid biochemistry and molecular biology 103.3 (2007): 405-410.‏
  25. Mohammad Beigi R, Afkhamzadeh A, Sadat Daneshpour N. The effect of calcium-vitamin D in efficacy of induction ovulation in infertile women with polycystic ovary syndrome. Iran J Obstet Gynecol Infertil 2012; 15(14):7-13. (Persian).
  26. Rashidi BH, Haghollahi F, Tehranian N, Shariat M, Zayerii F, Bagheri M, et al. Therapeutic effects of vitamin D and calcium in patients with polycystic ovary syndrome. J Reprod Infertil 2006; 7(3):225-33.
  27. Goodarzi MO, Dumesic DA, Chazenbalk G, Azziz R. Polycystic ovary syndrome: etiology, pathogenesis and diagnosis. Nat Rev Endocrinol 2011; 7(4):219-31.
  28. Bonakdaran S, Mazloom Khorasani Z, Davachi B, Taghi Shakeri M. Comparison of calcitriol and metformin effects on clinical and metabolic consequences of polycystic ovary syndrome. Iran J Obstet Gynecol Infertil 2012; 14(8):16-24. (Persian).
  29. Nestler JE, Reilly ER, Cheang KI, Bachmann LM, Downs RW Jr. A pilot study: effects of decreasing serum insulin with diazoxide on vitamin D levels in obese women with polycystic ovary syndrome. Trans Am Clin Climatol Assoc 2012; 123:209–19.
  30. Irani M, Minkoff H, Seifer DB, Merhi Z. Vitamin D increases serum levels of the soluble receptor for advanced glycation end products in women with PCOS. J Clin Endocrinol Metab 2014; 99(5):E886–90.
  31. Irani M, Merhi Z. Role of vitamin D in ovarian physiology and its implication in reproduction: a systematic review. Fertil Steril 2014; 102(2):460–8.
  32. Hillard PJ. Bening disease of the female reproductive tract symptoms and sign. In: Berek JS, editor. Novak's gynecology. 13th ed. Philadelphia: Lippincott William & Willkins; 2002. P. 351-420.
  33. Schwartz SM, Marshall LM, Baird DD. Epidemiologic contributions to understanding the etiology of uterine leiomyomata. Environ Health Perspect 2000; 108(Suppl 5):821-7.
  34. Feldman S, Stewart EA. The reproductive system and disease: uterine corpus. In: Ryan KJ, Berkowite BR, Barbieri RL, editors. Kistner's gynecology: principles and practice. 7th ed. Boston: Mosey; 1999. P. 121-42.
  35. Yao-Yuan H, Fuu-Jen T, Chi-Chen C, Chang-Hai T, Cheng-Chieh L, Lian-Shun Y. Cytochrome P450c17α (CYP17) gene polymorphism is not associated with leiomyoma susceptibility. Genet Mol Biol 2002; 25(4):361-4.
  36. Dehraisi M, Sadat S, Sadat SM, Davari Tanha F, Aghasadeghi MR, Bahramali G, et al. The effect of glutathione S-transferase gene polymorphisms on susceptibility to uterine myoma. Tehran Univ Med J 2015; 72(10):667-73. (Persian).
  37. Paffoni A, Somigliana E, Vigano P, Benaglia L, Cardellicchio L, Pagliardini L, et al. Vitamin D status in women with uterine leiomyomas. J Clin Endocrinol Metab 2013; 98(8):E1374–8.
  38. Ginde AA, Liu MC, Camargo CA Jr. Demographic differences and trends of vitamin D insufficiency in the US population, 1988–2004. Arch Intern Med 2009; 169(6):626–32.
  39. Wise LA, Ruiz-Narváez EA, Haddad SA, Rosenberg L, Palmer JR. Polymorphisms in vitamin D-related genes and risk of uterine leiomyomata. Fertil Steril 2014; 102(2):503–10.
  40. Halder SK, Sharan C, Al-Hendy O, Al-Hendy A. Paricalcitol, a vitamin d receptor activator, inhibits tumor formation in a murine model of uterine fibroids. Reprod Sci 2014; 21(9):1108–19.
  41. Serdar E, Bulun MD. Mechanisms of disease endometriosis. N Engl J Med 2009; 360:268-79.
  42. Sahin S, Beji NK. Assessment of quality of life of women with endometriosis. Hum Reprod 2012; 27:263-8.
  43. Stefansson H, Geirsson RT, Steinthorsdottir V, Jonsson H, Manolescu A, Kong A, et al. Genetic factors contribute to the risk of developing endometriosis. Hum Reprod 2002; 17(3):555-9.
  44. Hansen KA, Eyster KM. Genetics and genomics of endometriosis. Clin Obstet Gynecol 2010; 53(2):403-12.
  45. Yildirim B, Guler T, Akbulut M, Oztekin O, Sariiz G. 1-alpha,25-dihydroxyvitamin D3 regresses endometriotic implants in rats by inhibiting neovascularization and altering regulation of matrix metalloproteinase. Postgrad Med 2014; 126(1):104–10.
  46. Di Rosa M, Malaguarnera G, De Gregorio C, Palumbo M, Nunnari G, Malaguarnera L. Immuno-modulatory effects of vitamin D3 in human monocyte and macrophages. Cell Immunol 2012; 280(1):36–43.
  47. Somigliana E, Panina-Bordignon P, Murone S, Di Lucia P, Vercellini P, Vigano P. Vitamin D reserve is higher in women with endometriosis. Hum Reprod 2007; 22(8):2273–8.
  48. Mormile R, Vittori G. Vitamin D intake and endometriosis: the good and the bad. Eur J Obstet Gynecol Reprod Biol 2014; 177:152–3.
  49. Visser JA, de Joop FH, Laven JS, Themmen AP. Anti-Müllerian hormone: a new marker for ovarian function. Reproduction 2006; 131(1):1–9.
  50. Kelsey TW, Wright P, Nelson SM, Anderson RA, Wallace WH. A validated model of serum anti-müllerian hormone from conception to menopause. PLoS One 2011; 6(7):e22024.
  51. Seifer DB, Maclaughlin DT. Mullerian Inhibiting Substance is an ovarian growth factor of emerging clinical significance. Fertil Steril 2007; 88(3):539–46.
  52. Chang EM, Kim YS, Won HJ, Yoon TK, Lee WS. Association between sex steroids, ovarian reserve, and vitamin D levels in healthy nonobese women. J Clin Endocrinol Metab 2014; 99(7):2526–32.
  53. Malloy PJ, Peng L, Wang J, Feldman D. Interaction of the vitamin D receptor with a vitamin D response element in the Mullerian-inhibiting substance (MIS) promoter: regulation of MIS expression by calcitriol in prostate cancer cells. Endocrinology 2009; 150(4):1580–7.
  54. Merhi ZO, Seifer DB, Weedon J, Adeyemi O, Holman S, Anastos K, et al. Circulating vitamin D correlates with serum antimüllerian hormone levels in late-reproductive-aged women: Women’s Interagency HIV Study. Fertil Steril 2012; 98(1):228–34.
  55. Coticchio C, Sereni E, Serrao L, Mazzone S, Ladarola I, Borini A. What criteria for the definition of oocyte quality? Ann N Y Acad Sci 2004; 1034:132-44.
  56. Speroff L, Fritz MA. Assisted reproductive technology. In: Speroff L, Fritz MA, editors. Clinical gynecologic endocrinology and infertility. 7th ed. Philadelphia: Lippincott Williams & Wilkins; 2005. P. 1214-5.
  57. Simbar M, Hashemi S, Shams J, Majd HA. Association between infertile women’s anxiety with ART success rates. J Reprod Infertil 2009; 10(4):279-85. (Persian).
  58. Gougeon A. Regulation of ovarian follicular development in primates: facts and hypotheses. Endocr Rev 1996; 17(2):121-55.
  59. Danforth DN. Danforth's obstetrics and gynecology. Philadelphia: Lippincott Williams & Wilkins; 2008. P. 705-14
  60. Ozkan S, Jindal S, Greenseid K, Shu J, Zeitlian G, Hickmon C, et al. Replete vitamin D stores predict reproductive success following in vitro fertilization. Fertil Steril 2010; 94(4):1314–9.
  61. Rudick B, Ingles S, Chung K, Stanczyk F, Paulson R, Bendikson K. Characterizing the influence of vitamin D levels on IVF outcomes. Hum Reprod 2012; 27(11):3321–7.
  62. Rudick BJ, Ingles SA, Chung K, Stanczyk FZ, Paulson RJ, Bendikson KA. Influence of vitamin D levels on in vitro fertilization outcomes in donor-recipient cycles. Fertil Steril 2014; 101(2):447–52.
  63. Fabris A, Pacheco A, Cruz M, Puente JM, Fatemi H, Garcia-Velasco JA. Impact of circulating levels of total and bioavailable serum vitamin D on pregnancy rate in egg donation recipients. Fertil Steril 2014; 102(6):1608–12.
  64. Kwiecinski GG, Petrie GI, DeLuca HF. Vitamin D is necessary for reproductive functions of the male rat. J Nutr 1989; 119(5):741–4.
  65. Sun W, Chen L, Zhang W, Wang R, Goltzman D, Miao D. Active vitamin D deficiency mediated by extracellular calcium and phosphorus results in male infertility in young mice. Am J Physiol Endocrinol Metab 2015; 308(1):E51–62.
  66. Jensen MB. Vitamin D and male reproduction. Nat Rev Endocrinol 2014; 10(3):175–86.
  67. Blomberg Jensen M, Bjerrum PJ, Jessen TE, Nielsen JE, Joensen UN, Olesen IA, et al. Vitamin D is positively associated with sperm motility and increases intracellular calcium in human spermatozoa. Hum Reprod 2011; 26(6):1307–17.
  68. Yang B, Sun H, Wan Y, Wang H, Qin W, Yang L, et al. Associations between testosterone, bone mineral density, vitamin D and semen quality in fertile and infertile Chinese men. Int J Androl 2012; 35(6):783–92.
  69. Hammoud AO, Meikle AW, Peterson CM, Stanford J, Gibson M, Carrell DT. Association of 25-hydroxy-vitamin D levels with semen and hormonal parameters. Asian J Androl 2012; 14(6):855–9.
  70. Ramlau-Hansen CH, Moeller UK, Bonde JP, Olsen J, Thulstrup AM. Are serum levels of vitamin D associated with semen quality? Results from a cross-sectional study in young healthy men. Fertil Steril 2011; 95(3):1000–4.