تأثیر تمرینات مقاومتی- اینتروال با دو شدت متفاوت بر سیتوکراتین 18 و برخی شاخص های عملکردی در زنان مبتلا به کبد چرب

نوع مقاله: اصیل پژوهشی

نویسندگان

1 دانشجوی دکتری بیوشیمی و متابولیسم ورزشی، دانشکده علوم ورزشی، دانشگاه حکیم سبزواری، سبزوار، ایران.

2 استادیار گروه فیزیولوژی ورزشی، دانشکده علوم ورزشی، دانشگاه حکیم سبزواری، سبزوار، ایران.

3 دانشیار گروه فیزیولوژی ورزشی، دانشکده علوم ورزشی، دانشگاه حکیم سبزواری، سبزوار، ایران.

4 استادیار گروه داخلی، دانشکده علوم پزشکی، دانشگاه آزاد اسلامی، شاهرود، ایران

10.22038/ijogi.2020.15999

چکیده

مقدمه: امروزه شیوه‌های غیرتهاجمی در روند بررسی مرگ سلولی کبدی و استفاده از درمان‌های کمکی غیردارویی مورد توجه متخصصین سلامتی می­باشد. مطالعه حاضر با هدف مقایسه تأثیر تمرینات ترکیبی با شدت­های متفاوت بر CK18 (شاخص مرگ هپاتوسیت) و برخی شاخص­های عملکردی در زنان مبتلا به کبد چرب غیرالکلی انجام شد.
روش­‌کار: این مطالعه کاربردی و نیمه­تجربی با طرح پیش­آزمون و پس­آزمون در سال 1397 بر روی 33 زن مبتلا به کبد چرب غیرالکلی در شهرستان شاهرود انجام شد. افراد به‌صورت تصادفی به گروه­های تمرینی و کنترل تقسیم شدند. گروه تمرین ترکیبی 1، تمرین اینتروال هوازی (AIT) همراه با تمرین مقاومتی و گروه ترکیبی 2، تمرین اینتروال شدید (HIIT) به همراه تمرین مقاومتی را به‌مدت 12 هفته اجرا کردند. آزمون­های عملکردی (قدرت و استقامت بالاتنه و پایین تنه، توان هوازی) و نمونه­گیری خونی قبل و بعد از 12 هفته انجام شد. تجزیه و تحلیل داده‌ها با استفاده از نرم‌افزار آماری SPSS (نسخه 24) و R و آزمون‌ آنالیز واریانس با اندازه­گیری­های تکراری انجام شد. میزان p کمتر از 05/0 معنادار در نظر گرفته شد.
یافته­ها: بین دو گروه تمرینی در میزان CK18 تفاوت معناداری وجود داشت (001/0>p) و تمرین ترکیبی 1 باعث کاهش بیشتری در CK18 شد. همچنین هر دو نوع تمرین باعث افزایش معنادار قدرت بیشینه و استقامت عضلانی بالاتنه و پایین­تنه و VO2max و نیز کاهش معنادار درصد چربی بدن شد (001/0>p). در مقادیر وزن و شاخص توده بدنی تفاوت معناداری بین گروه‌ها مشاهده نشد (05/0<p).
نتیجه­گیری: زنان مبتلا به کبد چرب غیرالکلی احتمالاً بتوانند از هر دو تمرینی ترکیبی متوسط و شدید برای کاهش درصد چربی و بهبود شاخص­های عملکردی مستقل از کاهش وزن استفاده کنند و برای جلوگیری از مرگ سلولی از برنامه­های تمرین ترکیبی با شدت متوسط به‌عنوان یک درمان غیر­دارویی کمکی بهره گیرند.

کلیدواژه‌ها


عنوان مقاله [English]

Effect of resistance-interval training with two different intensities on cytokeratin18 and some functional parameters in women with fatty liver

نویسندگان [English]

  • Somayeh Rajabi 1
  • Roya Askari 2
  • Amir Hossein Haghighi 3
  • Nasrin Razaviyanzadeh 4
1 PhD student of Biochemistry and Sport Metabolism, School of Sport Sciences, Hakim Sabzevari University, Sabzevar, Iran.
2 Assistant Professor, Department of Sport Physiology, School of Sport Sciences, Hakim Sabzevari University, Sabzevar, Iran.
3 Associate Professor, Department of Sport Physiology, School of Sport Sciences, Hakim Sabzevari University, Sabzevar, Iran.3-Associate Professor, Department of Sport Physiology, School of Sport Sciences, Hakim Sabzevari University, Sabzevar, Iran.
4 Assistant Professor, Department of Internal Group, School of Medical Sciences, Islamic Azad University, Shahrood, Iran.
چکیده [English]

Introduction: Nowadays, noninvasive approaches in the investigation of hepatocyte death and the use of non-pharmacological adjunctive therapies are considered by health professionals. This study was performed with aim to compare the effect of different intensities of combined training on cytokeratin18 )marker of hepatocyte death( and some indicators of physical function in women with Non-alcoholic fatty liver disease.
Methods: This applied and semi-experimental study with pre-test and post-test design was performed on 33 women with NAFLD in Shahrood city in 2018. The subjects were randomly divided into training and control groups. Combined training 1 Group performed Aerobic Interval Training (AIT) along with resistance training and combined training 2 group performed High Intensity Interval Training (HIIT) along with resistance training for 12 weeks. Functional tests (Upper and lower strength and endurance, aerobic power) and blood samples were performed before and after 12 weeks of training. Data were analyzed by SPSS software (version 24)  and R statistical software and repeated measures ANOVA tests. PResults: There was significant difference between two training groups in the CK18 level (p<0.001) and combined training 1 group had higher decrease in the CK18 level. Also, both combined training significantly increased upper and lower maximal strength and muscular endurance and VO2max, as well as a significant decrease in body fat percentage (p<0.001). There was no significant difference between groups in weight and BMI (p>0.05).
Conclusion: Women with Non-alcoholic fatty liver disease may be able to use both intense and moderate combined training to reduce body fat percentage, improve physical performance indicators independent of weight loss and use moderate intensity combined training as a non-pharmacological adjunctive therapy to prevent cell death.

کلیدواژه‌ها [English]

  • Combined training
  • Cytokeratin18
  • Fatty liver
  • Functional parameters
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