عنوان مقاله [English]
Introduction: Despite many promising advances in recent years, our standing about the onset, progression, and metastasis of breast cancer is not yet complete. Many previous studies have focused mainly on the causes and treatment of breast cancer. However, it is believed that hormones in women may also play an import role in the onset and progression of breast cancer. Therefore, the present study is aimed at examining the association between prolactin levels and breast cancer in menopausal and pre-menopausal women.
Methods: This case-control study is conducted on 100 women with breast cancer visiting the Cancer Center of Peymaniye Hospital. The inclusion criteria included the patients diagnosed with breast cancer before going under surgery and chemoradiotherapy, and the exclusion criteria included tobacco consumers and people with other diseases. For this study, 25 menopausal volunteers with breast cancer, 25 pre-menopausal volunteers with breast cancer, and 50 others for the control group were randomly selected. The serum prolactin levels were measured by ELISA kits (Monobind, USA), and malondialdehyde levels were measured manually and based on the reaction with thiobarbituric acid. Descriptive statistics, such as mean and standard deviation, were used to analyze the data, and independent t-test was used for intragroup comparison. The data were entered using SPSS ver.21 software.