مقایسه سطح سرمی ویتامین D در بیماران تهدید به سقط و زنان با حاملگی نرمال

نوع مقاله : اصیل پژوهشی

نویسندگان

1 دانشجوی کارشناسی ارشد مامایی، کمیته تحقیقات دانشجویی، دانشکده پرستاری و مامایی، دانشگاه علوم پزشکی شهید بهشتی، تهران، ایران.

2 دانشیار گروه مامایی و بهداشت باروری، دانشکده پرستاری و مامایی، دانشگاه علوم پزشکی شهید بهشتی، تهران، ایران.

3 دانشیار گروه زنان و مامایی، دانشکده پزشکی، دانشگاه علوم پزشکی شهید بهشتی، تهران، ایران.

4 دانشجوی دکترای آمار زیستی، دانشکده پیراپزشکی، دانشگاه علوم پزشکی شهید بهشتی، تهران، ایران

چکیده

مقدمه: سقط خود‌به‌خود، شایع‌ترین عارضه حاملگی است. شناخت عوامل مرتبط با آن می‌تواند نقش مهمی در پیشگیری از آن و بهبود پیامد‌های بارداری ایفا کند. برخی مطالعات ارتباط بین کمبود ویتامین D در بارداری و سقط را مطرح کرده‌اند، لذا مطالعه حاضر با هدف مقایسه سطح سرمی ویتامین D در بیماران تهدید به سقط و زنان با حاملگی نرمال انجام شد.
روش‌کار: این مطالعه مورد شاهدی در سال 1397 بر روی 46 نفر از زنان باردار مراجعه‌کننده به بیمارستان‌های لقمان حکیم و مهدیه شهر تهران در دو گروه تهدید به سقط و بارداری نرمال کمتر از 20 هفته انجام شد. نمونه خون افراد مورد مطالعه از نظر سطح ویتامین D ارزیابی شد. تجزیه و تحلیل داده‌ها با استفاده از نرم‌افزار آماری SPSS (نسخه 16) و آزمون‌های تی مستقل، من‌ویتنی و کای دو انجام شد. میزان p کمتر از 05/0 معنی‌دار در نظر گرفته شد.
یافته‌ها: میانگین غلظتD (OH)25 در گروه مورد 22/9±49/22 و در گروه شاهد 03/10±36/30 نانوگرم بر میلی‌لیتر بود که اختلاف آماری معنی‌داری بین دو گروه وجود داشت (008/0=p).
نتیجه‌گیری: سطح سرمیD (OH)25 در زنان باردار تهدید به سقط پایین‌تر از زنان با بارداری نرمال است و سطح سرمی پایین ویتامین D می‌تواند به‌عنوان یک عامل خطر برای تهدید به سقط محسوب شود.

کلیدواژه‌ها

عنوان مقاله [English]

Comparison of serum vitamin D levels in threatened abortion patients and women with normal pregnancy

نویسندگان [English]

  • Elham Moghadas Inanloo 1
  • Zohre Keshavarz 2
  • Zahra Naeiji 3
  • Marziyeh Asgari 4
1 M.Sc. student of Midwifery, Student Research Committee, School of Nursing and Midwifery, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
2 Associate Professor, Department of Midwifery and Reproductive Health, School of Nursing and Midwifery, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
3 Associate Professor, Department of Obstetrics and Gynecology, Faculty of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
4 Ph.D. student in Biostatistics, School of Paramedical, Shahid Beheshti University of Medical Sciences, Tehran, Iran
چکیده [English]

Introduction: Spontaneous abortion is the most common complication of pregnancy. Identifying the associated factors can play an important role in preventing it and improving pregnancy outcomes. Some studies have suggested an association between vitamin D deficiency in pregnancy and abortion. Therefore, this study was performed with aim to compare serum levels of vitamin D in threatened-abortion patients and women with normal pregnancy.
Methods: This case-control study was performed in 2016 on 46 pregnant women referred to Loghman Hakim and Mahdieh hospitals in Tehran in two groups of threatened-abortion and normal pregnancy less than 20 weeks. Blood samples of the subjects were assessed for vitamin D serum level. Data were analyzed using SPSS software (version 16) and independent t-test, Mann-Whitney, and chi-square tests. P<0.05 was considered statistically significant.
Results: The mean of 25(OH)D concentration was 22.49 ±9.22 ng/ml in case group and 30.36 ±10.03 ng/ml in control group and there was a significant difference between the two groups (p = 0.008).
Conclusion: Serum 25(OH)D levels in threatened-abortion pregnant women are lower than in women with normal pregnancy. Low serum levels of vitamin D can be considered as a risk factor for threatened-abortion.

کلیدواژه‌ها [English]

  • Abortion
  • Pregnancy
  • Threatened-abortion
  • Vitamin D
  • Women

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مجله زنان، مامایی و نازایی ایران
دوره 22، شماره 10
دی 1398
صفحه 49-57

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