اثر داروهای مهارکننده رگزایی به همراه شیمی‌درمانی در درمان سرطان پستان: مطالعه مروری

نوع مقاله: مروری

نویسندگان

1 کارشناس ارشد فیزیولوژی، دانشکده پزشکی، دانشگاه علوم پزشکی مشهد، مشهد، ایران.

2 استادیار گروه ژنتیک، مرکز تحقیقات سندرم متابولیک، دانشکده پزشکی، دانشگاه علوم پزشکی مشهد، مشهد، ایران. استادیار گروه ژنتیک، مرکز تحقیقات سرطان، دانشکده پزشکی، دانشگاه علوم پزشکی مشهد، مشهد، ایران. استادیار گروه ژنتیک، گروه فناوری‌های نوین، دانشکده پزشکی، دانشگاه علوم پزشکی مشهد، مشهد، ایران.

3 استادیار گروه بیوشیمی، دانشکده پزشکی، دانشگاه علوم پزشکی مشهد، مشهد، ایران.

4 استاد گروه فیزیولوژی، دانشکده پزشکی، دانشگاه علوم پزشکی مشهد، مشهد، ایران.

چکیده

مقدمه: سرطان یکی از شایع‌ترین علل مرگ‌و‌میر در دنیاست و در این بین سرطان پستان به­عنوان دومین سرطان منجر به مرگ­ در میان زنان در سراسر جهان شناخته شده است. تومور پستان یک تومور ناهمگن است و مطالعات مختلف نشان داده­اند که آنژیوژنز یا رگ­زایی، نقش مهمی در توسعه و پیشرفت تومور بازی می­کند. مطالعات بالینی در ‌خصوص ارتباط داروهای مهارکننده­ رگ­زایی به‌همراه شیمی­درمانی در جهت بهبود رویه­ درمان سرطان پستان انجام شده است. مطالعه­ مروری حاضر با هدف بررسی اثر داروهای مهارکننده­ رگ­زایی به‌همراه شیمی­درمانی در بیماران مبتلا به سرطان پستان انجام شد.
روش­کار: در این مطالعه مروری جهت یافتن مقالات مرتبط پایگاه­های اطلاعاتی ISI، Google scholar، PubMed و Scopus با استفاده از کلمات کلیدی Breast cancer، Anti angiogenic drug، Chemotherapy و Angiogenesis از واژه­نامه پزشکی Mesh، بین سال‌های 2018-2000 جستجو شدند. در انتخاب مقالات، محدودیت زمانی در نظر گرفته نشد. انتخاب مقالات بر مبنای استفاده از داروهای ضدرگ­زایی به‌همراه شیمی­درمانی یا به‌عنوان بخشی از داروهای شیمی­درمانی در درمان سرطان پستان انجام گردید. در پایان کار نیز داده­های ورودی به‌صورت کیفی مورد تجزیه و تحلیل قرار گرفتند.
یافته­ها: بر­ اساس نتایج مطالعات، مشخص گردید که استفاده از داروهای مهار‌کننده رگ­زایی می­توانند به عنوان رویکردی در جهت بهبود درمان سرطان پستان تحت پژوهش­های بیشتری قرار گیرد. مهارکننده­های VEGF و VEGFR اثرات بالینی متفاوتی را از خود بروز داده­اند که می­تواند ناشی از تفاوت میزان دوز، طریقه مصرف و یا تداخلات دارویی باشد.
نتیجه­گیری: اگرچه داروهای مهار­کننده­ ­رگ­زایی نقش مثبتی در بهبود درمان سرطان پستان داشته­اند، اما با توجه به نتایج متفاوتی که در مطالعات بالینی در دوزها و روش استفاده از این داروها مشاهده شده است، مطالعات بیشتر در این خصوص ضروری است. هرچند به‌طور ‌کلی به‌نظر می‌رسد این داروها در کنار داروهای استاندارد شیمی­درمانی می‌توانند کاندید مناسبی برای درمان و افزایش طول عمر بیماران مبتلا به سرطان پستان باشند.

کلیدواژه‌ها


عنوان مقاله [English]

Effect of anti-angiogenic drugs along with chemotherapy in breast cancer treatment: review article

نویسندگان [English]

  • Najibeh Nasiri 1
  • Amir Avan 2
  • Seyed Mahdi Hassanian 3
  • Majid Khazaei 4
1 M.Sc. of Physiology, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
2 Assistant professor, Department of Genetic, Metabolic Syndrome Research Center, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran. Assistant professor, Department of Genetic, Cancer Research Center, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran. Assistant professor, Department of Genetic, Department of Modern Technologies, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
3 Assistant professor, Department of Biochemistry, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
4 Professor, Department of Physiology, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
چکیده [English]

Introduction: Cancer is one of the most common causes of death in the world and breast cancer is known as the second leading cause of death in women worldwide. Breast cancer is a heterogeneous tumor; various studies have shown that angiogenesis plays an important role in progression and development of cancer. Clinical studies have been performed on the relationship between anti-angiogenic drugs along with chemotherapy in improvement of breast cancer treatment. This review article was performed with aim to evaluate the effect of anti-angiogenic drugs along with chemotherapy in breast cancer treatment.
Methods: In this review study, the related articles were searched in databases of Scopus, PubMed, ISI and Google scholar by the key words including “Breast cancer”, “Anti-angiogenic drug”, ” Chemotherapy” and “Angiogenesis” in Mesh between 2000-2018. No time limitation was considered in selection of the articles. Selection of the articles was based on use of anti-angiogenic drugs along with chemotherapy or as part of chemotherapy drugs in breast cancer treatment. At the end of study, data were analyzed qualitatively.
Results: According to the studies’ results, it was determined that use of anti-angiogenic drugs in improving breast cancer treatment could be more investigated. VEGF and VEGFR inhibitors have shown different clinical effects that could be due to differences in dosage, method of consumption or drug interactions.
Conclusion: Although anti-angiogenic drugs have positive role in improving breast cancer treatment, since different results in doses and method of consumption of these drugs were observed in clinical trials, performing more studies in this regard is required. In general, it seems that these drugs in combination with standard chemotherapy agents could be a good candidate for treatment and increasing survival rate in breast cancer patients.

کلیدواژه‌ها [English]

  • Anti angiogenic drug
  • Breast Cancer
  • VEGF
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