مقایسه تأثیر کپسول آویشن شیرازی و ایبوپروفن بر پس‌درد زایمان

نوع مقاله: اصیل پژوهشی

نویسندگان

1 کارشناس ارشد مامایی، کمیته تحقیقات دانشجویی، دانشکده پرستاری و مامایی، دانشگاه علوم پزشکی شهید بهشتی تهران، تهران، ایران.

2 استادیار گروه مامایی و بهداشت باروری، مرکز تحقیقات مامایی و بهداشت باروری، دانشکده پرستاری و مامایی، دانشگاه علوم پزشکی شهید بهشتی تهران، تهران، ایران.

3 استاد گروه فارماکوگنوزی، دانشکده داروسازی و مرکز تحقیقات علوم دارویی، دانشگاه علوم پزشکی شهید بهشتی تهران، تهران، ایران.

4 استادیار گروه آمار زیستی، دانشکده پیراپزشکی، دانشگاه علوم پزشکی شهید بهشتی تهران، تهران، ایران.

5 دانشیار گروه زنان و مامایی، مرکز تحقیقات باروری، ناباروری و سلامت جنین، دانشگاه علوم پزشکی جندی شاپور اهواز، اهواز، ایران.

6 کارشناس مامایی، بیمارستان امام خمینی، دانشگاه علوم پزشکی جندی شاپور اهواز، اهواز، ایران

چکیده

مقدمه: پس‌دردهای زایمان، یکی از مشکلات شایع مادران است که برای تسکین آن، مادران به گیاهان دارویی روی می­آورند. طی سال‌های اخیر، عملکرد بالینی مبتنی بر شواهد مورد توجه قرار گرفته است، لذا مطالعه حاضر با هدف تعیین تأثیر کپسول آویشن شیرازی و ایبوپروفن بر پس‌درد زایمان انجام شد.
روش‌کار: اینمطالعه کارآزماییبالینیدوسوکور در سال 1395 برروی 100 مادر زایمان کرده به روش طبیعی مراجعه کننده به بیمارستان امام خمینی شهر اهواز انجام شد. زنان به‌طور تصادفی در گروه کپسول آویشن شیرازی و ایبوپروفن قرار گرفتند، سپس هر 6 ساعت به مدت 24 ساعت یک کپسول مصرف کردند. بررسی شدت پس‌درد زایمان قبل از هر بار مداخله و یک ساعت پس از هر بار مداخله با استفاده از مقیاس عددی درد مورد بررسی قرار گرفت. تجزیه و تحلیل داده­ها با استفاده از نرم‌افزار آماری SPSS (نسخه 18) و آزمون­های آماری من‌ویتنی، تی مستقل، کای دو و اندازه‌گیری مکرر انجام شد. میزان pکمتر از 05/0 معنی‌دار در نظر گرفته شد.
یافته‌ها: در این مطالعه دو گروه از نظر متغیرهای مورد مطالعه شامل: سن مادر (سال)، تعداد زایمان و وزن نوزاد اختلاف آماری معنی‌داری نداشتند (05/0<p). مقایسه میانگین شدت پس‌درد بین دو گروه بعد از چهارمین مداخله تفاوت آماری معنی‌داری نداشت (057/0=p) و در هر دو گروه شدت پس‌درد کاهش پیدا کرده بود.
نتیجه‌گیری: کپسول آویشن شیرازی مانند ایبوپروفن میزان پس‌درد زایمان را کاهش می­دهد.

کلیدواژه‌ها


عنوان مقاله [English]

Comparison of effects of Zataria multiflora capsule and Ibuprofen on postpartum pain

نویسندگان [English]

  • Ladan Parsa 1
  • Giti Ozgoli 2
  • Faraz Mojab 3
  • Maliheh Nasiri 4
  • Farideh Moramezi 5
  • Maryam Ghezi 6
1 M.Sc. in Midwifery, Student Research Committee, School of Nursing and Midwifery, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
2 Assistant Professor, Department of Midwifery and Reproductive Health, Midwifery and Reproductive Health Research Center, School of Nursing and Midwifery, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
3 Professor, Department of Pharmacognosy, School of Pharmacy and Pharmaceutical Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
4 Assistant Professor, Department of Biostatistics, Faculty of Paramedical Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
5 Associate Professor, Department of Obstetrics and Gynecology, Fertility Infertility and Perinatology Research Center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.
6 B.Sc. in Midwifery, Imam Khomeini Hospital, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.
چکیده [English]

Introduction: Postpartum pain is one of the common problems in mothers، and mothers tend to use medicinal plants for soothing the pain. In recent years، the clinical performance، according to evidence، was noticed. Therefore، this clinical trial was designed and implemented to determine the effects of Zataria multiflora Boiss capsule and Ibuprofen on postpartum pain.
Method: This randomized double-blinded clinical trial was performed on 100 mothers that had natural vaginal birth in Imam Khomeini hospital in Ahwaz in 2016. The women were randomly assigned into two groups of Zataria multiflora Boiss capsule and Ibuprofen. Then, the subjects received one capsule every 6 h for 24 h. The pain intensity was studied before each intervention and 1 h after that using the numerical scale of pain. The data were analyzed by SPSS software (version 18) and statistical tests, including Mann-Whitney U test، t-test، Chi-square test, and Repeated measures. P-value less than 0.05 was considered statistically significant.
Results:In this study, both groups had no statistically significant difference in the interventions, such as the age، number of delivery, and weight of neonate (P>0/05). Comparing the mean scores of postpartum pain intensity between the two groups after the fourth intervention showed no significant difference (P=0/057), and in both groups, the intensity of postpartum pain decreased.
Conclusion: According to the results of the present study, Zataria moltiflora Boiss capsule similar to Ibuprofen can decrease the postpartum pain intensity.

کلیدواژه‌ها [English]

  • postnatal care
  • Pain
  • Zataria Moltiflora Boiss
  • Herbal Medicine
  • Clinical trial
  1. Hall JE, Guyton AC. Textbook of medical physiology. London: Saunders; 2011.
  2. Holdcroft A, Snidvongs S, Cason A, Doré CJ, Berkley KJ. Pain and uterine contractions during breast feeding in the immediate post-partum period increase with parity. Pain 2003; 104(3):589-96.
  3. Deussen AR, Ashwood P, Martis R. Analgesia for relief of pain due to uterine cramping/involution after birth. Cochrane Database Syst Rev 2011; 5:CD004908.
  4. Cunningham F, Leveno K, Bloom S, Hauth J, Rouse DJ, Spong CY. Williams obstetrics. New York, NY, USA: McGraw-Hill Companies, Inc; 2014.
  5. Trevor AJ, Katzung BG, Masters SB. Basic & clinical pharmacology. New York: McGraw-Hill Medical; 2009.
  6. Dennehy CE. The use of herbs and dietary supplements in gynecology: an evidence‐based review. J Midwifery Womens Health 2006; 51(6):402-9.
  7. Amin G. The most traditional Iranian herbs. 2nd ed. Tehran: Tehran University of Medical Sciences and Medical Ethics and History Research Center; 2008. (Persian).
  8. Ramezani M, Hosseinzadeh H, Samizadeh S. Antinociceptive effects of Zataria multiflora Boiss fractions in mice. J Ethnopharmacol 2004; 91(1):167-70.
  9. Van Den Broucke CO, Lemli JA. Spasmolytic activity of the flavonoids from Thymus vulgaris. Pharm Weekblad Sci 1983; 5(1):9-14.
  10. Iravani M. Clinical effects of Zataria multiflora essential oil on primary dysmenorrhea. J Med Plants 2009; 8(30):54-168.
  11. Akhondzadeh SH. Encyclopedia of Iranian medicinal plants. Institue of Medicinal Plants. Tehran: Jahad-e Daneshgahi; 2000. (Persian).
  12. Karamali J. Encyclopedia of Iranian medicinal plants. Tehran: Publication Thriller; 2013. (Persian).
  13. Yahya S, Ozgoli G, Mojab F, Alavi Majd H, Shojaee A, Mirhaghjou N. The effect of hypericum perforatum cream on perineal pain after episiotomy in primiparous women. Iran J Obstet Gynecol Infertil 2015; 18(159):1-7. (Persian).
  14. Williamson A, Hoggart B. Pain: a review of three commonly used pain rating scales. J Clin Nurs 2005; 14(7):798-804.
  15. Farrar JT, Troxel AB, Stott C, Duncombe P, Jensen MP. Validity, reliability, and clinical importance of change in a 0-10 numeric rating scale measure of spasticity: a post hoc analysis of a randomized, double-blind, placebo-controlled trial. Clin Ther 2008; 30(5):974-85.
  16. Melzack R, Wall PD. Textbook of pain. London: Churchill Livingstone; 1999.
  17. Hawker GA, Mian S, Kendzerska T, French M. Measures of adult pain: visual analog scale for pain (VAS pain), numeric rating scale for pain (NRS pain), mcgill pain questionnaire (MPQ), short‐form mcgill pain questionnaire (SF‐MPQ), chronic pain grade scale (CPGS), short form‐36 bodily pain scale (SF‐36 BPS), and measure of intermittent and constant osteoarthritis pain (ICOAP). Arthritis Care Res 2011; 63(Suppl 11):S240-52.
  18. Chang SR, Chen KH, Lin HH, Chao YM, Lai YH. Comparison of the effects of episiotomy and no episiotomy on pain, urinary incontinence, and sexual function 3 months postpartum: a prospective follow-up study. Int J Nurs Stud 2011; 48(4):409-18.
  19. Ozgoli G, Khodadadie A, Sheikhan Z, Jambarsang S, Mojab F, Taleb S. Comparison of efficacy between herbal capsule of anise and mefenamic acid on after-pain. J Med Plants 2017; 2(62):38-49.
  20. Shadipour M, Simbar M, Salamzadeh J, Nasire N. A comparative study on the effects of Menstrogol and Mefenamic acid on postpartum after-pain. Iran South Med J 2014; 16(6):401-9.
  21. Silvan A, Abad M, Bermejo P, Villar A. Effects of compounds extracted from Santolina oblongifolia on TXB2 release in human platelets. Inflammopharmacology 1998; 6(3):255-63.
  22. Arbabian S, Izadi HR, Ghoshouni H, Shams J, Zardouz H, Kamalinezhad M, et al. Effect of water extract of saffron (Crocus sativus) on chronic phase of formaline test in female mice. Kowsar Med J 2009; 14(1):11-8. (Persian).
  23. Heidari MR, Asadi Pour A, Sepehri GH, Atapour N. Study of the analgesic effect of pimpinella anisun extract by tail-flick and formalin test in mice. J Babol Univ Med Sci 1999; 1(3):42-51.
  24. Salamon I. Chamomile: a medicinal plant. Rome: The Herb, Spice and Medicinal Plant Digest; 1992.
  25. Masoumi AY, Abbasnejad M, Derakhshanfar A, Esmaeilpour BK, Mostafavi SA. Effect of matricaria recutita l. aqueous extract on acetic acid-induced ulcerative colitis in adult male rats. Physiol Pharm 2010; 14(3):269-80.
  26. Modarres M, Mirmohhamad AM, Oshrieh Z, Mehran A. Comparison of the effect of mefenamic acid and matricaria camomilla capsules on primary dysmenorrhea. J Babol Univ Med Sci 2011; 13(3):50-8.
  27. Abedian Z, Rezvani Fard M, Asili J, Esmaeili H, Dadgar S. Comparison of the effect of chamomile matricaria and mefenamic acid capsules on postpartum hemorrhage in women with postpartum pain. Iran J Obstet Gynecol Infertil 2016; 19(14):1-8. (Persian).
  28. Biniaz V. A review of the world-wide researches on the therapeutic effects of ginger during the past two years. Jentashapir J Health Res 2013; 4(4):333-7.
  29. Grzanna R, Lindmark L, Frondoza CG. Ginger-an herbal medicinal product with broad anti-inflammatory actions. J Med Food 2005; 8(2):125-32.
  30. Shirvani MA, Motahari-Tabari N, Alipour A. The effect of mefenamic acid and ginger on pain relief in primary dysmenorrhea: a randomized clinical trial. Arch Gynecol Obstet 2015; 291(6):1277-81.
  31. Ozgoli G, Goli M, Moattar F, Valaie N. Comparing ginger with mefenamic acid and ibubrofen for the treatment of primary dysmenorrhea. Res Med 2007; 31(1):61-5.
  32. Kheiriyat F, Tadayon Najafabadi M, Mousavi P, Haghighizadeh H, Namjuyan F. Effect of Dill essence and mefenamic acid on postpartum pain. Iran J Obstet Gynecol Infertil 2016; 19(4):8-16. (Persian).
  33. Gharib Naseri MK, Pilehvaran AA, Shamansouri N. Investigating the spasmolytic activity of celery (Apium Graveolens) leaf hydroalcoholic extract on rat's ileum. J Feyz 2007; 11(3):1-7.
  34. Bahmani M, Shirzad H, Majlesi M, Shahinfard N, Rafieian-Kopaei M. A review study on analgesic applications of Iranian medicinal plants. Asian Pac J Trop Med 2014; 7:S43-53.
  35. Golabi S, Rohampour K. Effect of aqueous extract of Drosera Spatulata on firing rate of paragigantocellularis nucleus neurons after pain induction by formalin in rats. Physiol Pharmacol 2010; 14(3):281-7.
  36. Lopes LS, Pereira SS, Silva LL, Figueiredo KA, Moura BA, Almeida FR, et al. Antinociceptive effect of topiramate in models of acute pain and diabetic neuropathy in rodents. Life Sci 2009; 84(3-4):105-10.
  37. Mokhtari M, Shariati M, Niknam H. The effect of antinociceptive and anti inflammatory of hydro-alcohol extract of dorema aucheri on formalin test and carrageenan model in rat. J Rafsanjan Univ Med Sci Health Serv 2008; 7(3):165-72. (Persian).