بررسی تأثیر کپسول بهارنارنج بر افسردگی زنان در دوره پس از زایمان

نوع مقاله: اصیل پژوهشی

نویسندگان

1 مربی گروه مامایی، دانشکده علوم پزشکی نیشابور، نیشابور، ایران.

2 استادیار گروه روانپزشکی، دانشکده پزشکی، دانشگاه علوم پزشکی سبزوار، سبزوار، ایران.

3 استادیار گروه فارماکولوژی، مرکز تحقیقات سلولی و مولکولی، دانشکده پزشکی، دانشگاه علوم پزشکی سبزوار، سبزوار، ایران.

4 کارشناس مامایی، کمیته تحقیقات دانشجویی، دانشکده پزشکی، دانشگاه علوم پزشکی سبزوار، سبزوار، ایران.

5 کارشناس ارشد اپیدمیولوژی، مرکز تحقیقات متاآنالیز، دانشگاه علوم پزشکی تربت حیدریه، تربت حیدریه ، ایران.

چکیده

مقدمه: افسردگی پس از زایمان، از شایع‌ترین مشکلات بهداشت عمومی در اولین سال بعد از زایمان محسوب می­شود. برخی علائم این اختلال شامل: خلق افسرده، احساس گناه، از دست دادن اشتها و اختلال خواب می‌باشد. افسردگی می‌تواند مشکلات جدی برای کودک، مادر و خانواده ایجاد کند، لذا مطالعه حاضر با هدف تعیین تأثیرکپسول بهارنارنج بر افسردگی زنان در دوره پس از زایمان انجام شد.
روش‌کار: این مطالعه کارآزمایی بالینی تصادفی شده در سال 1396 بر روی 49 مادر مراجعه کننده به مراکز بهداشتی و درمانی سبزوار انجام شد. شرکت‌کنندگان از پرسشنامه استاندارد افسردگی بک (BDI-II)، نمره بین 28-14 داشتند، سپس افسردگی آنان توسط مصاحبه با روانپزشک تأیید شد. سپس به روش بلوک‌بندی تصادفی به دو گروه مداخله (بهارنارنج 500 میلی‌گرم/ 2 بار در روز+ فلوکستین 20 میلی‌گرم روزانه) و گروه کنترل (فلوکستین 20 میلی‌گرم روزانه به اضافه پلاسبو) تقسیم شدند. درمان در هفته 8 پس از زایمان آغاز شد و به مدت 8 هفته ادامه یافت. تجزیه و تحلیل داده­ها با استفاده نرم‌افزار آماری SPSS (نسخه 16) و آزمون‌های کولموگروف- اسمیرنوف، کای اسکوئر، تی مستقل و زوجی و من‌ویتنی انجام شد. میزان p کمتر از 05/0 معنادار در نظر گرفته شد.
یافته‌ها: میانگین نمره افسردگی بعد از مداخله در گروه بهارنارنج 02/4±2/9 و در گروه کنترل 56/3±12/17 بود که بین دو گروه اختلاف آماری معناداری وجود داشت (001/0>p). همچنین بعد از مداخله، 15 نفر (5/62%) از گروه بهارنارنج و تنها 1 نفر (4%) از گروه کنترل، فاقد افسردگی پس از زایمان بودند.
نتیجه‌گیری: مصرف بهارنارنج به همراه فلوکستین در درمان افسردگی خفیف تا متوسط در دوران پس از زایمان مؤثرتر از مصرف فلوکستین به‌تنهایی است، لذا می‌توان از آن به‌عنوان مکمل در درمان افسردگی پس از زایمان استفاده کرد.

کلیدواژه‌ها


عنوان مقاله [English]

The effect of Citrus aurantium capsule on postpartum depression in women

نویسندگان [English]

  • Zahra Zare 1
  • Mohammad Reza Shegarf Nakhaee 2
  • Bahare Amin 3
  • Fateme Neghabi 4
  • Samira Yazdani 4
  • Zeynab Bidel 5
1 Instructor, Department of Midwifery, Neyshabur University of Medical Sciences, Neyshabur, Iran.
2 Assistant Professor, Department of Psychiatry, Faculty of Medicine, Sabzevar University of Medical Sciences, Sabzevar, Iran.
3 Assistant Professor, Department of Pharmacology, Cellular and Molecular Research Center, Faculty of Medicine, Sabzevar University of Medical Sciences, Sabzevar, Iran.
4 BC of Midwifery, Student Research Committee, Faculty of Medicine, Sabzevar University of Medical Sciences, Sabzevar, Iran.
5 M.Sc. of Epidemiology, Meta-Analysis Research Center, Torbat Heydariyeh University of Medical Sciences, Torbat Heydariyeh, Iran.
چکیده [English]

Introduction: Postpartum depression is a common public health problem in the first year after birth. Low mood, feeling guilty, loss of appetite, difficulty in falling asleep are some symptoms of this condition. Depression can cause serious problems for the child, mother and family. This study was performed with aim to determine the effect of Citrus aurantium on postpartum depression in women.
Methods: This randomized clinical trial was conducted on 49 mothers referred to the Sabzevar health and treatment centers in 2017. Participants had the score of 14-28 on the Beck Depression Inventory-Second Edition (BDI-II), and their depression was confirmed by a psychiatrist through interview. They were randomly (with random blocking method) assigned to the treatment group (orange blossom 500 mg/Bid+ fluoxetine 20 mg) and control group (fluoxetine 20 mg plus placebo). Treatment was started on week 8 after delivery and continued for 8 weeks. Data were analyzed using SPSS software (version 16) and Kolmogrov-Smirnov, Chi-square, Independent and paired t‑test and Mann–Whitney test. P<0.05 was considered statistically significant.
Results: The mean score of depression after the intervention in Citrus aurantium group was 9.2±4.02 and in control group was 17.12±3.56; there was a significant difference between two groups (p>0,001). Also, after the intervention, 15 women (62.5%) in Citrus aurantium group and 1)4%( in control group were without postpartum depression.
Conclusion: The use of Citrus aurantium along with fluoxetine in the treatment of mild to moderate postpartum depression is more effective than fluoxetine alone. So, it can be used as an alternative in treatment of postpartum depression.

کلیدواژه‌ها [English]

  • Bitter orange
  • Citrus aurantium
  • Medicinal Plants
  • Postpartum Depression
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