تأثیر لوپوس اریتماتوی سیستمیک بر عملکرد جنسی زنان: یک مطالعه مرور سیستماتیک و متاآنالیز

نوع مقاله: مروری

نویسندگان

1 دانشجوی دکترای بهداشت ‌باروری، کمیته تحقیقات دانشجویی، دانشکده پرستاری و مامایی، دانشگاه علوم پزشکی مشهد، مشهد، ایران.

2 استادیار گروه آمار و اپیدمیولوژی، مرکز تحقیقات مدیریت و تعیین کننده‌های اجتماعی سلامت، دانشکده بهداشت، دانشگاه علوم پزشکی مشهد، مشهد، ایران.

3 مرکز تحقیقات مراقبت پرستاری و مامایی، دانشگاه علوم پزشکی مشهد، مشهد، ایران. استادیار گروه مامایی، دانشکده پرستاری و مامایی، دانشگاه علوم پزشکی مشهد، مشهد، ایران

4 دانشیار گروه زنان و مامایی، دانشکده پزشکی، دانشگاه علوم پزشکی مشهد، مشهد، ایران.

چکیده

مقدمه: لوپوس اریتماتوی سیستمیک یک بیماری التهابی، خودایمنی و مزمن، با درگیری چندارگانی و دوره­های عود و بهبود است که عمدتاً زنان را متأثر می­سازد. یکی از مهم‌ترین چالش­های زنان به لوپوس، اثرات نامطلوب این بیماری بر عملکرد جنسی زنان است. مرور سیستماتیک و متاآنالیز حاضر با هدف بررسی تأثیر لوپوس بر عملکرد جنسی زنان انجام شد.
روش‌کار: در این مطالعه مرور سیستماتیک برای جستجوی مقالات فارسی و انگلیسی پایگاه­های اطلاعاتی PubMed،Magiran ، Scopus، SID، Google scholar با استفاده از کلمات کلیدی انگلیسی Systemic Lupus Erythematosus، Sexual functioning، sexual activity، sexual disorder و کلمات کلیدی فارسی شامل: لوپوس اریتماتوی سیستمیک، عملکرد جنسی، اختلال جنسی، فعالیت جنسی با استفاده از عملگرهای بولین OR و AND در طی سال‌های 2000 تا دسامبر 2017 جستجو شدند. تحلیل داده­ها با نرم‌افزار STATA (نسخه 1/14) انجام شد. جهت بررسی ناهمگنی بین مطالعات از شاخص I2 و جهت ترکیب داده­ها و انجام متاآنالیز از مدل اثرات تصادفی استفاده شد.
یافته‌ها: در مجموع 8 مقاله از 515 مطالعه مرتبط با تأثیر لوپوس بر عملکرد جنسی زنان استخراج گردید که از این تعداد 4 مطالعه وارد آنالیز کمی شد. یافته­های مطالعات وارد شده به متاآنالیز نشان داد که بر اساس مدل اثرات تصادفی لوپوس اریتماتوی سیستمیک باعث کاهش عملکرد جنسی زنان می­شود (001/0=p؛ 25/2-10/1: CI 95%؛ 58/1=RR).
نتیجه­گیری: با توجه به تأثیر منفی لوپوس بر عملکرد جنسی زنان، نتایج این مطالعه می‌تواند زمینه‌ای برای طراحی و اجرای برنامه­های مراقبت سلامت جنسی زنان مبتلا به لوپوس باشد تا منجر به ارتقاء سلامت جنسی این گروه از زنان گردد.

کلیدواژه‌ها


عنوان مقاله [English]

The effect of systemic lupus erythematosus on women's sexual function: A systematic review and meta-analysis

نویسندگان [English]

  • Nahid Maleki-Saghooni 1
  • Hamid Heidarian Miri 2
  • Fatemeh Zahra Karimi 3
  • Masoumeh Mirteimouri 4
1 Ph.D. student of Reproductive Health, Students Research Committee, School of Nursing and Midwifery, Mashhad University of Medical Sciences, Mashhad, Iran.
2 Assistant Professor, Department of Statistics and Epidemiology, Management & Social Determinants of Health Research Center, School of Health, Mashhad University of Medical Sciences, Mashhad, Iran.
3 Nursing and Midwifery Care Research Center, Mashhad University of Medical Sciences, Mashhad, Iran. Assistant Professor, Department of Midwifery, School of Nursing and Midwifery, Mashhad University of Medical Sciences, Mashhad, Iran.
4 Associate Professor, Department of Obstetrics and Gynecology, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
چکیده [English]

Introduction: Systemic lupus erythematosus (SLE) is an inflammatory, autoimmune, chronic disease with multi-organ involvement with a remitting and relapsing course that mainly affects women. One of the most important challenges for women affected by SLE is the adverse impacts of the disease on Sexual function. This systematic review and meta-analysis was conducted with am to investigate the effects of lupus on women's sexual function.
Methods: In this systematic review and meta-analysis study, both Persian and English articles were searched in databases of PubMed, Magiran, Scopus, SID, Google scholar using the keywords of "Systemic Lupus Erythematosus", "Sexual functioning", "sexual activity", "sexual disorder" and their Persian equivalents during 2000 up to December 2017. Data analysis was performed with STATA software (version 14.1). I2 test was used to assess the heterogeneitybetween studies and the random effects model was applied to pool data and perform meta-analysis.
Results: A total of 8 articles of 515 studies about the impact of lupus on women's sexual function were extracted, of which 4 studies were included in the quantitative analysis. The findings of included studies into meta-analysis showed that based on the random effects model, systemic lupus erythematosus decreased women's sexual function )RR= 1.58; 95% CI: 1.10-2.25; p=0.001).
Conclusion: Considering the negative impact of lupus on women's sexual function, findings of this study can be a basis for designing and implementation of sexual health programs for this group of women so that lead to promotion of their sexual health.

کلیدواژه‌ها [English]

  • Sexual function
  • systemic lupus erythematosus
  • Women
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