Third Month Pap Smear After Radiotherapy: A Predictive Factor of Response to Treatment in Cervical Cancer
Fatemeh
Homaei Shandiz
Associate professor, Department of Radiotherapy and Oncology, Solid Tumor Treatment Research Center, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
author
Sareh
Hosseini
Assistant professor, Department of Radiotherapy and Oncology, Solid Tumor Treatment Research Center, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
author
Zohreh
Yousefi
Professor, Department of Obstetrics and Gynecology, Ovulation Disorder Research Center, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
author
Nourieh
Sharifi
Professor, Department of Pathology, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
author
text
article
2014
per
Introduction: Cervical cancer is the most common gynecological cancer. Due to the effect of radiation on cervical mucosa, evaluation of response to radiotherapy with pap smear is controversial. This study was performed with the aim to evaluate the value of post-radiation pap smear as a predictive factor of tumor response. Methods: This cross-sectional study was performed during three years (2005-2008) on 30 patients with stage IIB cervical cancer who referred to oncology department of Mashhad Ghaem and Omid hospitals. Patients who continued their follow up with pap smear and gynecologic exam at the end of radiotherapy, 1, 3 and 24 months later were entered to the study. Response to radiotherapy based on pap smear and gynecologic exam at different times after the end of radiation were compared with each other and also were compared with the results of similar evaluations at the second year. Those with abnormal pap smear and diagnosis of recurrence at the end of third month were excluded from the study. Results: According to complete concordance between pap smear and clinical exam 24 months after radiotherapy, we assumed this time as the reference for response. The concordance rate of pap smear results at the end of radiation treatment,1 month and three months after treatment, with pap smear results 24 months after radiation were 70% (p=0.088), 50% (p=0.043) and 97% (0.033), respectively. The pap smear had 100% sensitivity, 95.8% specificity and 97% diagnostic accuracy at the end of third months after radiation. Conclusion: Pap smear at the end of radiotherapy did not indicate treatment failure or poor patient outcome. Otherwise, Pap smear 3 months after radiation can be used as a predictive factor for response to treatment.
The Iranian Journal of Obstetrics, Gynecology and Infertility
Mashhad University of Medical Sciences
1680-2993
17
v.
126
no.
2014
1
8
https://ijogi.mums.ac.ir/article_3775_3fc2efc0585970f2429356f2e346a0e0.pdf
dx.doi.org/10.22038/ijogi.2014.3775
The frequency of ovarian masses and lesions in different age categories in Khorram Abad (1381-1391)
Maryam
Hasani
PhD Student of reproductive health, Department of reproductive health, Student Research Committee, School of Nursing and Midwifery, Shahroud University of Medical Sciences, Shahroud, Iran.
author
Sajjad
Alizadeh
General Practitioner, Student Research Committee, School of Medicine, Ilam University of Medical Sciences, Ilam, Iran.
author
Pari
Bastami
M.Sc. Student of Midwifery, School of Nursing and Midwifery, Ahvaz University of Medical Sciences, Khouzestan, Iran.
author
Farnaz
Soheyli
Bachelor of Midwifery, School of Nursing and Midwifery, Lorestan University of Medical Sciences, Lorestan, Iran.
author
text
article
2014
per
Introduction: Ovarian cancer is the second most common cancer of the reproductive organs and the most common cause of death from malignancy of reproductive organs. Ovarian tumors are very different in terms of histology. The studies showed a large variation in prevalence and types of ovarian tumors at different ages. This study was performed with the aim to evaluate the frequency of the ovarian lesions at different age categories. Methods: this descriptive study was performed on 350 ovarian pathology samples of women referred to Pathology Center of Khorram Abad Shohadaye Ashayer during 2002-2012. Data related to physical examination and demographic data and chief complain of patients obtained from archival records and if necessary contact with them. The vague pathology specimens and insufficient records were excluded. Data was analyzed by SPSS statistical software (version 16). P< 0.05 was considered significant. Results: 83.4% of masses were related to reproductive ages that 91.4% of them were benign and the malignant tumors were predominantly observed in pre and post menopausal ages. Many masses were discovered and removed during other abdominal surgeries such as appendectomy that mostly were in reproductive ages andmost of them were benign. Conclusions: despite functional cysts are more common in reproductive ages, the highest prevalence of ovarian malignant lesions are seen in pre and post menopausal ages that Cerocyst adenocarsinoma is the most common. According to the increased prevalence of ovarian malignancies in these age categories, follow up of the masses in these age groups is very important. Therefore, it is recommended that this subject be given more importance in the annual examinations.
The Iranian Journal of Obstetrics, Gynecology and Infertility
Mashhad University of Medical Sciences
1680-2993
17
v.
126
no.
2014
9
16
https://ijogi.mums.ac.ir/article_3776_7e9ff8c90adf75e61b700b1da9f9f552.pdf
dx.doi.org/10.22038/ijogi.2014.3776
Pregnancy outcomes in pregnant women with hypothyroidism (A review Article)
Sima
Nazarpour
Ph.D student of Reproductive Health, School of Nursing and Midwifery, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
author
Fahimeh
Ramezani Tehrani
Professor, Department of Obstetrics and Gynecology, Reproductive Endocrinology Research Center, Research Institute of Endocrinology, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
author
Masoumeh
Simbar
Associate professor, Department of Reproductive and Midwifery, School of Nursing and Midwifery, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
author
Freidoon
Azizi
Professor, Department of Endocrine and metabolism, Research Institute of Endocrinology, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
author
text
article
2014
per
Introduction: Hypothyroidism is considered as the most common thyroid disorder during pregnancy and about 2-3% of pregnant women suffer from this disorder. Furthermore, 10-20% of all pregnant women are positive for TPO antibodies and euthyroidism. Some studies have indicated that these slight thyroid dysfunctions could also be related to poor maternal and fetal outcomes. This study was performed with the aim to increase awareness and provide a review on adverse effect of hypothyroidism on pregnancy outcomes. Methods: In this review and prospective study, databases of Medline, Embase and the Cochrane Library were searched with appropriate keywords for relevant English manuscript. In this study, variety of studies including randomized clinical trials, cohort (prospective and retrospective), case-control and case reports that were about thyroid dysfunctions and their adverse outcome in pregnancy were used. Among 3480 articles foumd from the electronic searches in the beginning of the study, there were 400 related articles that 130 studies were related to overt hypothyroidism, 203 related to subclinical hypothyroidism and 67 related to thyroid safety. Of these articles, 47 cases were in line with the objectives of the study that included 22 studies about hypothyroidism and 26 about thyroid safety. Results: Overt hypothyroidism has several adverse effects on pregnancy outcomes, but there is debate on short and long term effect of subclinical hypothyroidism, and thyroid antibody positivity. Also, there is no consensus on feto-maternal complication of pregnant women with normal function of thyroid and TPO antibody positive. Conclusions: Although the impact of autoimmune thyroid disease on pregnancy outcomes is generally accepted, however the effect of subclinical hypothyroidism without increasing TPOAb on pregnancy outcomes is controversial. Further studies on maternal and neonatal outcomes in mother's subclinical thyroid dysfunction are needed.
The Iranian Journal of Obstetrics, Gynecology and Infertility
Mashhad University of Medical Sciences
1680-2993
17
v.
126
no.
2014
17
26
https://ijogi.mums.ac.ir/article_3777_cc7f8b6c8f209f5e47947467c9bf05bf.pdf
dx.doi.org/10.22038/ijogi.2014.3777